ArticleBMC research notes2018
The dental infections in patients undergoing preoperative dental examination before surgical treatment of saccular intracranial aneurysm.
Article in BMC research notes, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 23 citations in OpenAlex.
- The oral microbiota: new insight into intracranial aneurysms.Annals of medicine · 2025Review
- Association between periodontitis and rupture of saccular intracranial aneurysms: a multicenter cross-sectional study.Neurosurgical review · 2025Article
- Oral microbiota and central nervous system diseases: A review.Neuroprotection (Chichester, England) · 2025Review
- Oral bacterial genic expression detection in aneurysm wall of a French population sample - preliminary monocentric study.Neurosurgical review · 2024Article
- The Role of Gut and Oral Microbiota in the Formation and Rupture of Intracranial Aneurysms: A Literature Review.International journal of molecular sciences · 2023Review
- Torque Teno virus DNA is found in the intracranial aneurysm wall-Is there a causative role?Frontiers in medicine · 2023Article
- Article
- Role of oral pathogens in the pathogenesis of intracranial aneurysm: review of existing evidence and potential mechanisms.Neurosurgical review · 2021Review
- Surrounding vascular geometry associated with basilar tip aneurysm formation.Scientific reports · 2020Article
- Periodontitis and gingival bleeding associate with intracranial aneurysms and risk of aneurysmal subarachnoid hemorrhage.Neurosurgical review · 2020Article
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveDental bacterial DNA and bacterial-driven inflammation markers have previously been detected in intracranial aneurysm tissue samples. This study aimed (i) to assess the possible presence of dental infectious foci, (ii) and the possible association between typical odontogenic bacteria and clinical dental findings in patients undergoing pre-operative dental examination before surgical treatment of saccular intracranial aneurysm. Ninety patients with an intracranial aneurysm were recruited to the study, and the patients' teeth were routinely investigated. Clinical data and bacterial samples from the gingival pockets were collected from a subpopulation of 60 patients. Five typical dental pathogens and total bacteria amounts were measured from gingival samples using real-time quantitative PCR.
resultsThe amounts of total bacterial and Fusobacterium nucleatum DNA were significantly higher in the patients with ≥ 6 mm gingival pockets than patients without them (p < 0.01 and p < 0.01, respectively). A total of 43% of patients with an aneurysm had gingival pockets of 6 mm or deeper. Dental infectious foci are fairly common in the Finnish population, with the prevalence of severe periodontitis being around 20%. The frequency of chronic dental infections, especially periodontitis seems to be higher in patients with intracranial aneurysm.
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Registered trials
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