Evidence map›Paper›PMID 30126367›Full record

ArticleBMC cancer2018

A novel approach to monitoring the efficacy of anti-tumor treatments in animal models: combining functional MRI and texture analysis.

Ming Meng, Huadan Xue, Jing Lei, Qin Wang, Jingjuan Liu, Yuan Li, Ting Sun, Haiyan Xu, Zhengyu Jin

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC cancer, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Ming MengDepartment of Radiology, Chinese Academy of Medical Sciences & Peking Union Medical College, Peking Union Medical College Hospital, No.1 Shuaifuyuan, Dongcheng District, Beijing, 100730, China.
Huadan XueDepartment of Radiology, Chinese Academy of Medical Sciences & Peking Union Medical College, Peking Union Medical College Hospital, No.1 Shuaifuyuan, Dongcheng District, Beijing, 100730, China.
Jing LeiDepartment of Radiology, Chinese Academy of Medical Sciences & Peking Union Medical College, Peking Union Medical College Hospital, No.1 Shuaifuyuan, Dongcheng District, Beijing, 100730, China.
Qin WangDepartment of Radiology, Chinese Academy of Medical Sciences & Peking Union Medical College, Peking Union Medical College Hospital, No.1 Shuaifuyuan, Dongcheng District, Beijing, 100730, China.
Jingjuan LiuDepartment of Radiology, Chinese Academy of Medical Sciences & Peking Union Medical College, Peking Union Medical College Hospital, No.1 Shuaifuyuan, Dongcheng District, Beijing, 100730, China.
Yuan LiDepartment of Radiology, Chinese Academy of Medical Sciences & Peking Union Medical College, Peking Union Medical College Hospital, No.1 Shuaifuyuan, Dongcheng District, Beijing, 100730, China.
Ting SunDepartment of Radiology, Chinese Academy of Medical Sciences & Peking Union Medical College, Peking Union Medical College Hospital, No.1 Shuaifuyuan, Dongcheng District, Beijing, 100730, China.
Haiyan XuDepartment of Biomedical Engineering, Chinese Academy of Medical Sciences & Peking Union Medical College, Institute of Basic Medical Sciences, No.5 Dongdan, Dongcheng District, Beijing, 100730, China.
Zhengyu JinDepartment of Radiology, Chinese Academy of Medical Sciences & Peking Union Medical College, Peking Union Medical College Hospital, No.1 Shuaifuyuan, Dongcheng District, Beijing, 100730, China. zhengyu_jin@126.com.

Funding

the National Key Technology Support Program of China 2012BAI23B06
6 · The paper itself

Abstract

backgroundThe aim of this study was to evaluate the early anti-tumor efficiency of different therapeutic agents with a combination of multi-b-value DWI, DCE-MRI and texture analysis.

methodsEighteen 4 T1 homograft tumor models were divided into control, paclitaxel monotherapy and paclitaxel and bevacizumab combination therapy groups (n = 6) that underwent multi-b-value DWI, DCE-MRI and texture analysis before and 15 days after treatment.

resultsAfter treatment, the tumors in the control group were significantly larger than those in the combination group (P = 0.018). In multi-b-value DWI, the ADC

conclusionAll these results suggest some strong correlations among DWI, DCE and texture analysis, which are beneficial for further study and clinical research.

Indexed as

AllograftsAnimalsAntineoplastic Combined Chemotherapy ProtocolsBevacizumabBreast NeoplasmsContrast MediaDiffusion Magnetic Resonance ImagingDisease Models, AnimalFemaleHumansMammary Neoplasms, AnimalMicePaclitaxelTreatment OutcomeBevacizumabContrast MediaPaclitaxelBreast cancerFunctional MRIMultiparameter imagingNeoadjuvant chemotherapyTexture analysis

Identifiers

PMID30126367
PMCPMC6102870

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.