Evidence map›Paper›PMID 30126337›Full record

ArticleOtolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery2019

Impact of PET/CT on Staging and Treatment of Advanced Head and Neck Squamous Cell Carcinoma.

Jeffery B Jorgensen, Russell B Smith, Andrew Coughlin, William C Spanos, Michele M Lohr, Steven M Sperry, Oleg Militsakh, Robert P Zitsch, Bevan Yueh, Laura M Dooley and 3 more

Open access · greenAbstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.4field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 16 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Utilization of PET/CT Scan in Head and Neck Carcinoma: A Tertiary Care Hospital Experience.Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India · 2022
    Article
  5. Article
  6. Impact of pretreatment second lookClinical and translational radiation oncology · 2021
    Article
  7. Article
  8. Review
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 6 institutions in 1 country.

Jeffery B Jorgensen1 Department of Otolaryngology-Head and Neck Surgery, School of Medicine, University of Missouri, Columbia, Missouri, USA.
Russell B Smith2 Division of Surgical Oncology, Baptist MD Anderson Cancer Center, Jacksonville, Florida, USA.
Andrew Coughlin3 Department of Otolaryngology-Head and Neck Surgery, University of Nebraska Medical Center, Omaha, Nebraska, USA.
William C Spanos4 Department of Otolaryngology-Head and Neck Surgery, Sanford Health, Sioux Falls, South Dakota, USA.
Michele M Lohr4 Department of Otolaryngology-Head and Neck Surgery, Sanford Health, Sioux Falls, South Dakota, USA.
Steven M Sperry5 Department of Otolaryngology-Head and Neck Surgery, University of Iowa, Iowa City, Iowa, USA.
Oleg Militsakh3 Department of Otolaryngology-Head and Neck Surgery, University of Nebraska Medical Center, Omaha, Nebraska, USA.
Robert P Zitsch1 Department of Otolaryngology-Head and Neck Surgery, School of Medicine, University of Missouri, Columbia, Missouri, USA.
Bevan Yueh6 Department of Otolaryngology, University of Minnesota, Minneapolis, Minnesota, USA.
Laura M Dooley1 Department of Otolaryngology-Head and Neck Surgery, School of Medicine, University of Missouri, Columbia, Missouri, USA.
Aru Panwar3 Department of Otolaryngology-Head and Neck Surgery, University of Nebraska Medical Center, Omaha, Nebraska, USA.
Tabitha L I Galloway1 Department of Otolaryngology-Head and Neck Surgery, School of Medicine, University of Missouri, Columbia, Missouri, USA.
Nitin A Pagedar5 Department of Otolaryngology-Head and Neck Surgery, University of Iowa, Iowa City, Iowa, USA.
University of Missouri · USUniversity of Nebraska Medical Center · USSanford Health · USUniversity of Iowa · USBaptist Cancer Center · USUniversity of Minnesota · US

Funding

Viral VectorP30CA086862 · NCI · UNIVERSITY OF IOWA · PI Douglas Robert Spitz · 2000 to 2026
$70.0M
The Impact of PD-1 Inhibition on Immune-Response to ChemoradiotherapyP20GM103548 · NIGMS · SANFORD RESEARCH/USD · PI MISKIMINS, W KEITH · 2012 to 2020
$20.8M
Chemokine-mediated antigen-specific T cell responses and immunotherapies to treat head and neck cancerR01DE029524 · NIDCR · MICHIGAN STATE UNIVERSITY · PI PYEON, DOHUN, SPANOS, WILLIAM CHARLES · 2020 to 2024
$3.2M
Immune Dysregulation by Human Papillomavirus during Head and Neck Cancer ProgressionR01DE026125 · NIDCR · UNIVERSITY OF COLORADO DENVER · PI PYEON, DOHUN, SPANOS, WILLIAM CHARLES · 2016 to 2020
$2.8M
CENTER FOR CANCER BIOLOGY RESEARCHP20RR024219 · NCRR · SANFORD RESEARCH/USD · PI MISKIMINS, W KEITH · 2011 to 2011
$2.3M
NCRR NIH HHS P20 RR024219NIDCR NIH HHS R01 DE026125NIDCR NIH HHS R01 DE029524NIGMS NIH HHS P20 GM103548
6 · The paper itself

Abstract

objectiveTo understand the effects of positron emission tomography/computed tomography (PET/CT) evaluation on patients with previously untreated head and neck squamous cell carcinoma (HNSCC) with clinical evidence of regional lymph node involvement. STUDY

designProspective blinded study.

settingTertiary care cancer center. SUBJECTS AND

methodsInformed consent was obtained and data collected from 52 consecutive previously untreated patients with HNSCC and clinical evidence of cervical metastasis. All patients underwent conventional evaluation for HNSCC and whole body PET/CT. Data were evaluated by 5 independent reviewers, who performed TNM staging per the American Joint Committee on Cancer (seventh edition) manual and proposed a treatment plan prior to viewing, and after reviewing, PET/CT. Cases where at least 3 of 5 reviewers agreed were considered significant.

resultsThere were 0 patients for whom review of the PET/CT altered the T-class assessment (95% CI, 0-6.8), 12 (23.1%) for whom PET/CT altered N classification (95% CI, 12.5-34.5), and 2 (3.8%) for whom PET/CT altered the M classification (95% CI, 0.5-13.2). For 5 patients (9.6%), overall stage was altered per PET/CT review (95% CI, 3.2-21). For 3 patients (5.8%), PET/CT findings prompted reviewers to alter treatment recommendations (95% CI, 1.2-15.9).

conclusionWhen added to more conventional patient evaluation, PET/CT results in changes to the TNM categories, but overall staging and treatment were less frequently affected. Whether PET/CT should be used routinely for patients with stage III and IV HNSCC is still subjective and merits further study.

Indexed as

AdultAgedCohort StudiesFemaleHead and Neck NeoplasmsHumansMaleMiddle AgedNeoplasm InvasivenessNeoplasm StagingPositron Emission Tomography Computed TomographyPrognosisProspective StudiesSensitivity and SpecificitySingle-Blind MethodSquamous Cell Carcinoma of Head and NeckcarcinomaPET/CTtumor staging

Identifiers

PMID30126337
PMCPMC8893991
OpenAlexW2888362369

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.