ArticleInternational journal of environmental research and public health2018
Aluminium in Brain Tissue in Multiple Sclerosis.
Article in International journal of environmental research and public health, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 44 citations in OpenAlex.
- Impacts of Consumption of Ultra-Processed Foods on the Maternal-Child Health: A Systematic Review.Frontiers in nutrition · 2022Pooled it
- Review
- Zeolite and Neurodegenerative Diseases.Molecules (Basel, Switzerland) · 2024Review
- Aluminium in the Human Brain: Routes of Penetration, Toxicity, and Resulting Complications.International journal of molecular sciences · 2023Review
- Potentially toxic elements in the brains of people with multiple sclerosis.Scientific reports · 2023Article
- Vitamin D Resistance as a Possible Cause of Autoimmune Diseases: A Hypothesis Confirmed by a Therapeutic High-Dose Vitamin D Protocol.Frontiers in immunology · 2021Article
- Metal Imbalance in Neurodegenerative Diseases with a Specific Concern to the Brain of Multiple Sclerosis Patients.International journal of molecular sciences · 2020Review
- The contribution of orthodontic braces to aluminum exposure in humans: an experimental in vitro study.Environmental science and pollution research international · 2020Article
- Aluminum and Neurofibrillary Tangle Co-Localization in Familial Alzheimer's Disease and Related Neurological Disorders.Journal of Alzheimer's disease : JAD · 2020Article
- Unequivocal imaging of aluminium in human cells and tissues by an improved method using morin.Histochemistry and cell biology · 2019Article
- Aluminium in Brain Tissue in Epilepsy: A Case Report from Camelford.International journal of environmental research and public health · 2019Article
- Increased Aluminum Content in Certain Brain Structures is Correlated with Higher Silicon Concentration in Alcoholic Use Disorder.Molecules (Basel, Switzerland) · 2019Article
- Intracellular Aluminium in Inflammatory and Glial Cells in Cerebral Amyloid Angiopathy: A Case Report.International journal of environmental research and public health · 2019Article
- EDTA Chelation Therapy for the Treatment of Neurotoxicity.International journal of molecular sciences · 2019Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Multiple sclerosis (MS) is a devastating and debilitating neurodegenerative disease of unknown cause. A consensus suggests the involvement of both genetic and environmental factors of which the latter may involve human exposure to aluminium. There are no data on the content and distribution of aluminium in human brain tissue in MS. The aluminium content of brain tissue from 14 donors with a diagnosis of MS was determined by transversely heated graphite furnace atomic absorption spectrometry. The location of aluminium in the brain tissue of two donors was investigated by aluminium-specific fluorescence microscopy. The aluminium content of brain tissue in MS was universally high with many tissues bearing concentrations in excess of 10 μg/g dry wt. (10 ppm) and some exceeding 50 ppm. There were no statistically significant relationships between brain lobes, donor age or donor gender. Aluminium-specific fluorescence successfully identified aluminium in brain tissue in both intracellular and extracellular locations. The association of aluminium with corpora amylacea suggests a role for aluminium in neurodegeneration in MS.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.