ArticleInternational journal of environmental research and public health2018
Association of Bisphenol A Exposure with LINE-1 Hydroxymethylation in Human Semen.
Article in International journal of environmental research and public health, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 2 syntheses or guidelines pooled it, 45 citations in OpenAlex.
- Temporal and geographic variability of bisphenol levels in humans: A systematic review and meta-analysis of international biomonitoring data.Environmental research · 2025Pooled it
- Relationship between degree of methylation of sperm long interspersed nuclear element-1 (LINE-1) gene and alteration of sperm parameters and age: a meta-regression analysis.Journal of assisted reproduction and genetics · 2024Pooled it
- Unravelling male infertility through epigenetics: present understanding and future challenges.Mammalian genome : official journal of the International Mammalian Genome Society · 2026Review
- Transgenerational exposure to plastics-derived endocrine-disrupting bisphenol A and its analogs on male infertility: impact of gut dysbiosis and epigenetic regulation.Frontiers in endocrinology · 2026Review
- Endocrine Disruptors, Gut Microbiota, and Type 2 Diabetes: Bridging Mechanisms to Probiotic-Based Therapeutic Approaches.Diabetes, metabolic syndrome and obesity : targets and therapy · 2026Review
- The Effect of Organic Materials on the Response of the Soil Microbiome to Bisphenol A.Molecules (Basel, Switzerland) · 2025Article
- Review
- The impact of Bisphenol-A on human reproductive health.Toxicology reports · 2024Review
- Association of living environmental and occupational factors with semen quality in chinese men: a cross-sectional study.Scientific reports · 2023Article
- The Effects of Bisphenol A on Human Male Infertility: A Review of Current Epidemiological Studies.International journal of molecular sciences · 2023Review
- Re-evaluation of the risks to public health related to the presence of bisphenol A (BPA) in foodstuffs.EFSA journal. European Food Safety Authority · 2023Article
- The adverse role of endocrine disrupting chemicals in the reproductive system.Frontiers in endocrinology · 2023Review
- Multi- and Transgenerational Effects of Environmental Toxicants on Mammalian Reproduction.Cells · 2022Review
- Determination of bisphenol A in commercial cat food marketed in the Czech Republic.Journal of feline medicine and surgery · 2022Article
- An insight into bisphenol A, food exposure and its adverse effects on health: A review.Frontiers in nutrition · 2022Review
- Bisphenol A Induces Accelerated Cell Aging in Murine Endothelium.Biomolecules · 2021Article
- Environmental and occupational exposures associated with male infertility.Arhiv za higijenu rada i toksikologiju · 2021Review
- White rot fungi can be a promising tool for removal of bisphenol A, bisphenol S, and nonylphenol from wastewater.Environmental science and pollution research international · 2020Review
- Environmental Epigenetics and Genome Flexibility: Focus on 5-Hydroxymethylcytosine.International journal of molecular sciences · 2020Review
- Bisphenol A-Induced Epigenetic Changes and Its Effects on the Male Reproductive System.Frontiers in endocrinology · 2020Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Bisphenol A (BPA), an exogenous endocrine-disrupting chemical, has been shown to alter DNA methylation. However, little information is available about the effect of BPA exposure on DNA hydroxymethylation in humans. The objective of the present study was to examine whether BPA exposure was associated with DNA hydroxymethylation in human semen samples. We measured urine BPA levels and LINE-1 hydroxymethylation in 158 male factory workers selected from an occupational cohort study conducted in China between 2004 and 2008. Among them, there were 72 male workers with occupational BPA exposure (BPA-exposed group) and 86 male workers without occupational BPA exposure (unexposed group). Multivariate linear regression models were used to examine the association of exposure to BPA with LINE-1 hydroxymethylation. LINE-1 was more highly hydroxymethylated in the BPA-exposed group than in the unexposed group (median 12.97% vs. 9.68%, respectively;
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.