ArticleInternational journal of molecular sciences2018
Effects of Er:YAG and Diode Laser Irradiation on Dental Pulp Cells and Tissues.
Article in International journal of molecular sciences, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it, 30 citations in OpenAlex.
- Clinical efficacy of diode laser for pulpotomy in primary teeth: a meta-analysis of randomised controlled trials.Acta odontologica Scandinavica · 2025Pooled it
- Differential Response of Stro-1Journal of functional biomaterials · 2026Article
- Application of the Er:YAG laser in pulpotomy for mature permanent teeth with pulpitis: An animal study.PloS one · 2026Article
- Effects of laser regulation on anti-inflammatory and osteogenic differentiation of periodontal ligament stem cells though NF-κB signaling pathway.BMC oral health · 2025Article
- Effects of Semiconductor Laser Irradiation on Differentiation of Human Dental Pulp Stem Cells in Co-Culture with Dentin.Dentistry journal · 2024Article
- Photobiomodulation Therapy and Pulp-Regenerative Endodontics: A Narrative Review.Bioengineering (Basel, Switzerland) · 2023Review
- Current Applications and Future Directions of Lasers in Endodontics: A Narrative Review.Bioengineering (Basel, Switzerland) · 2023Review
- Reactive Oxygen Species Enlightened Therapeutic Strategy for Oral and Maxillofacial Diseases-Art of Destruction and Reconstruction.Biomedicines · 2022Review
- Pulpal and periapical tissue response after direct pulp capping with endosequence root repair material and low-level laser application.BMC oral health · 2022Article
- Improvement of apical papilla cell attachment after erbium, chromium-doped yttrium, scandium, gallium, and garnet laser application: a study in an ex vivo immature tooth model.Lasers in medical science · 2022Article
- Photobiomodulation reduces inflammation but does not influence the hypoxia-inducible factor-1α in pulp tissue of rats after bleaching.Journal of applied oral science : revista FOB · 2022Article
- Influence of low-level laser therapy on inflammation, collagen fiber maturation, and tertiary dentin deposition in the pulp of bleached teeth.Clinical oral investigations · 2020Article
- Characterization of Living Dental Pulp Cells in Direct Contact with Mineral Trioxide Aggregate.Cells · 2020Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Vital pulp therapy (VPT) is to preserve the nerve and maintain healthy dental pulp tissue. Laser irradiation (LI) is beneficial for VPT. Understanding how LI affects dental pulp cells and tissues is necessary to elucidate the mechanism of reparative dentin and dentin regeneration. Here, we show how Er:YAG-LI and diode-LI modulated cell proliferation, apoptosis, gene expression, protease activation, and mineralization induction in dental pulp cells and tissues using cell culture, immunohistochemical, genetic, and protein analysis techniques. Both LIs promoted proliferation in porcine dental pulp-derived cell lines (PPU-7), although the cell growth rate between the LIs was different. In addition to proliferation, both LIs also caused apoptosis; however, the apoptotic index for Er:YAG-LI was higher than that for diode-LI. The mRNA level of odontoblastic gene markers-two dentin sialophosphoprotein splicing variants and matrix metalloprotease (MMP)20 were enhanced by diode-LI, whereas MMP2 was increased by Er:YAG-LI. Both LIs enhanced alkaline phosphatase activity, suggesting that they may help induce PPU-7 differentiation into odontoblast-like cells. In terms of mineralization induction, the LIs were not significantly different, although their cell reactivity was likely different. Both LIs activated four MMPs in porcine dental pulp tissues. We helped elucidate how reparative dentin is formed during laser treatments.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.