ArticleAlimentary pharmacology & therapeutics2018
A comparison of the risk of postoperative recurrence between African-American and Caucasian patients with Crohn's disease.
Article in Alimentary pharmacology & therapeutics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 14 citations in OpenAlex.
- Inequalities in Healthcare Access, Experience and Outcomes in Adults With Inflammatory Bowel Disease: A Scoping Review.Inflammatory bowel diseases · 2024Article
- Clinical Predictors of Early and Late Endoscopic Recurrence Following Ileocolonic Resection in Crohn's Disease.Journal of Crohn's & colitis · 2024Article
- The Current State of Care for Black and Hispanic Inflammatory Bowel Disease Patients.Inflammatory bowel diseases · 2023Review
- Mild neoterminal ileal post-operative recurrence of Crohn's disease conveys higher risk for severe endoscopic disease progression than isolated anastomotic lesions.Alimentary pharmacology & therapeutics · 2022Article
- Characterization of Crohn's disease patients in Egypt: Risk factors for postoperative recurrence (A cohort study).Annals of medicine and surgery (2012) · 2021Article
- Black Race and Public Insurance Are Predictive of Inappropriate Evaluation of Iron Deficiency Anemia and Diarrhea.Digestive diseases and sciences · 2021Article
- Inflammatory polyps occur more frequently in inflammatory bowel disease than other colitis patients.BMC gastroenterology · 2020Article
- Differential risk of disease progression between isolated anastomotic ulcers and mild ileal recurrence after ileocolonic resection in patients with Crohn's disease.Gastrointestinal endoscopy · 2019Article
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Authors and funding
16 authors at 1 institution in 1 country.
Funding
Abstract
backgroundMany patients with Crohn's disease will develop complications that require surgery. Recurrence after surgery is common.
aimTo assess racial differences in postoperative recurrence between African-Americans and Caucasians.
methodsMedical records of Crohn's disease patients who underwent surgery (ileal, colonic, or ileocolonic resection) between June 2014 and June 2016 were reviewed. The primary endpoints were clinical and endoscopic remission at 6-12 months after a Crohn's disease surgery. Secondary outcomes included biological and histologic remission. Risks of recurrence were assessed by univariate, multivariate, and propensity score-matched analysis.
resultsThirty-six African-American and 167 Caucasian patients with Crohn's disease were included for analysis. There was no difference in disease location, disease behaviour, type of surgery performed, and pre- or postoperative medication use between the two groups. The rate of endoscopic remission did not differ between African-American and Caucasian patients (50% vs 42%, P = 0.76), and race did not influence the risk of endoscopic recurrence on univariate, multivariate, or propensity score-matched analysis. The rate of clinical remission was significantly lower in African-American patients compared to Caucasian patients (36% vs. 63%, P = 0.008). African-American race was significantly associated with clinical recurrence on univariate (odds ratio (OR) 6.76, 95% CI 1.50-30.40; P = 0.01), multivariate (OR 5.02, 95% CI 1.60-15.80; P = 0.006), and propensity-matched analysis (68% vs. 32% in Caucasians, P = 0.005). Rates of biologic and histologic remission were similar between the two groups on all analyses.
conclusionsWe found that African-American patients with Crohn's disease have a similar degree of objective measures of mucosal inflammation after surgery including endoscopic recurrence as compared to Caucasian patients. However, African-American race was significantly associated with clinical recurrence, suggesting the presence of ethnic variation in postoperative presentation in Crohn's disease.
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