Evidence map›Paper›PMID 30125956›Full record

ReviewThe Journal of physiology2019

Pulmonary vascular dysfunction in metabolic syndrome.

Conor Willson, Makiko Watanabe, Atsumi Tsuji-Hosokawa, Ayako Makino

Open access · bronzeAbstract readReview
In one paragraph

Review in The Journal of physiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
1.3field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 28 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Review
  5. Article
  6. Article
  7. Review
  8. Review
  9. The Metabolic Syndrome, a Human Disease.International journal of molecular sciences · 2024
    Review
  10. Article
  11. Review
  12. Article
  13. Article
  14. Article
  15. Review
  16. Pathways to Severe COVID-19 for People with Obesity.Obesity (Silver Spring, Md.) · 2021
    Review
  17. Article
  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Conor WillsonDepartment of Physiology, University of Arizona, Tucson, AZ, USA.ORCID 0000-0003-3981-4290
Makiko WatanabeDepartment of Physiology, University of Arizona, Tucson, AZ, USA.
Atsumi Tsuji-HosokawaDepartment of Physiology, University of Arizona, Tucson, AZ, USA.ORCID 0000-0001-8226-2618
Ayako MakinoDepartment of Physiology, University of Arizona, Tucson, AZ, USA.ORCID 0000-0003-1259-8604
University of Arizona · US

Funding

Coronary Endothelial Cell Dysfunction in Diabetes: Role of MFGE8R01HL142214 · NHLBI · UNIVERSITY OF FLORIDA · PI Yun Sok Lee, Ayako Makino · 2018 to 2026
$3.2M
Role of Gap Junction in Hypoxia-induced Pulmonary HypertensionR01HL146764 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI MAKINO, AYAKO · 2019 to 2022
$1.6M
NHLBI NIH HHS R01 HL142214NHLBI NIH HHS R01 HL146764
6 · The paper itself

Abstract

Metabolic syndrome is a critically important precursor to the onset of many diseases, such as cardiovascular disease, and cardiovascular disease is the leading cause of death worldwide. The primary risk factors of metabolic syndrome include hyperglycaemia, abdominal obesity, dyslipidaemia, and high blood pressure. It has been well documented that metabolic syndrome alters vascular endothelial and smooth muscle cell functions in the heart, brain, kidney and peripheral vessels. However, there is less information available regarding how metabolic syndrome can affect pulmonary vascular function and ultimately increase an individual's risk of developing various pulmonary vascular diseases, such as pulmonary hypertension. Here, we review in detail how metabolic syndrome affects pulmonary vascular function.

Indexed as

AnimalsEndothelium, VascularHumansHypertension, PulmonaryLungMetabolic SyndromeMuscle, Smooth, VascularDiabetesdyslipidemiaInsulin resistanceobesitypulmonary arterypulmonary hypertension

Identifiers

PMID30125956
PMCPMC6375868
OpenAlexW2888384906

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.