ArticleMedical physics2018
Technical Note: A benchtop cone-beam x-ray fluorescence computed tomography (XFCT) system with a high-power x-ray source and transmission CT imaging capability.
Article in Medical physics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Monte carlo study of detection limit for gold nanoparticles within small animal sized object during benchtop X-ray fluorescence computed tomography.Scientific reports · 2026Article
- Deep learning based rapid X-ray fluorescence signal extraction and image reconstruction for preclinical benchtop X-ray fluorescence computed tomography applications.Scientific reports · 2025Article
- Monte Carlo Modeling of An Experimental Benchtop L-shell X-ray Fluorescence Imaging/CT System Adopting Two Silicone Drift Detectors.Nuclear instruments & methods in physics research. Section A, Accelerators, spectrometers, detectors and associated equipment · 2025Article
- A High-Sensitivity Benchtop X-Ray Fluorescence Emission Tomography (XFET) System With a Full-Ring of X-Ray Imaging-Spectrometers and a Compound-Eye Collimation Aperture.IEEE transactions on medical imaging · 2024Article
- Sensitivity enhancement of an experimental benchtop x-ray fluorescence imaging system by deploying a single crystal cadmium telluride detector system optimized for high flux x-ray operations.Nuclear instruments & methods in physics research. Section A, Accelerators, spectrometers, detectors and associated equipment · 2022Article
- Use of the Fully Spectroscopic Pixelated Cadmium Telluride Detector for Benchtop X-Ray Fluorescence Computed Tomography.IEEE access : practical innovations, open solutions · 2022Article
- Bias-voltage dependent operational characteristics of a fully spectroscopic pixelated cadmium telluride detector system within an experimental benchtop x-ray fluorescence imaging setup.Biomedical physics & engineering express · 2021Article
- Article
- Characterization of a Pixelated Cadmium Telluride Detector System Using a Polychromatic X-Ray Source and Gold Nanoparticle-Loaded Phantoms for Benchtop X-Ray Fluorescence Imaging.IEEE access : practical innovations, open solutions · 2021Article
- Monte Carlo study of x-ray detection configurations for benchtop x-ray fluorescence computed tomography of gold nanoparticle-loaded objects.Physics in medicine and biology · 2020Article
- Quantitative X-ray fluorescence imaging of gold nanoparticles using joint L1 and total variation regularized reconstruction.Quantitative imaging in medicine and surgery · 2020Article
- Quantitative Imaging of Gd Nanoparticles in Mice Using Benchtop Cone-Beam X-ray Fluorescence Computed Tomography System.International journal of molecular sciences · 2019Article
- A detector's eye view (DEV)-based OSEM algorithm for benchtop x-ray fluorescence computed tomography (XFCT) image reconstruction.Physics in medicine and biology · 2019Article
- Investigation of transmission computed tomography (CT) image quality and x-ray dose achievable from an experimental dual-mode benchtop x-ray fluorescence CT and transmission CT system.Journal of X-ray science and technology · 2019Article
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3 authors.
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Abstract
purposeThis report describes upgrades and performance characterization of an experimental benchtop cone-beam x-ray fluorescence computed tomography (XFCT) system capable of determining the spatial distribution and concentration of metal probes such as gold nanoparticles (GNPs). Specifically, a high-power (~3 kW) industrial x-ray source and transmission CT capability were deployed in the same platform under the cone-beam geometry.
methodsAll components of the system are described in detail, including the x-ray source, imaging stage, cadmium-telluride detector for XFCT, and flat-panel detector for transmission CT imaging. The general data acquisition scheme for XFCT and transmission CT is also explicated. The detection limit of the system was determined using calibration samples containing water and GNPs at various concentrations. Samples were then embedded in a small-animal-sized phantom and imaged with XFCT and CT. The reconstructed XFCT and CT images were compared and analyzed using the contrast-to-noise ratio for each GNP-containing region of interest. Also, measurements of the incident beam spectra used for XFCT and CT imaging were made and the corresponding x-ray dose rates were estimated, along with the imaging dose.
resultsThe present configuration produced a GNP detection limit of 0.03 wt. % with the delivery of an effective dose of 1.87 cGy per projection. XFCT scan of an animal-sized phantom containing low concentrations (down to 0.03 wt. %) of GNP-loaded inserts can be performed within an hour.
conclusionsThe high performance of the system combined with the ability to perform transmission CT in tandem with XFCT suggests that the currently developed benchtop cone-beam XFCT/CT system, in conjunction with GNPs, can be used for routine multimodal preclinical imaging tasks with less stringent dose constraints such as ex vivo imaging. With further effort to minimize XFCT imaging dose as discussed in this report, it may also be used for in vivo imaging.
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