Evidence map›Paper›PMID 30125808›Full record

ArticleRedox biology2018

Hydrogen peroxide derived from NADPH oxidase 4- and 2 contributes to the endothelium-dependent vasodilatation of intrarenal arteries.

Mercedes Muñoz, María Pilar Martínez, María Elvira López-Oliva, Claudia Rodríguez, César Corbacho, Joaquín Carballido, Albino García-Sacristán, Medardo Hernández, Luis Rivera, Javier Sáenz-Medina and 1 more

Open access · goldAbstract read
In one paragraph

Article in Redox biology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
3.1field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 65 citations in OpenAlex.

  1. Review
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  3. The role of NO, HBasic research in cardiology · 2025
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  5. Overexpression of adipose tissue ERα enhances PVAT anticontractility via NOX4-derived HAmerican journal of physiology. Heart and circulatory physiology · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Mercedes MuñozDepartamento de Fisiología, Facultad de Farmacia, Universidad Complutense, Madrid, Spain.
María Pilar MartínezDepartamento de Anatomía y Embriología, Facultad de Veterinaria, Universidad Complutense, Madrid, Spain.
María Elvira López-OlivaDepartamento de Fisiología, Facultad de Farmacia, Universidad Complutense, Madrid, Spain.
Claudia RodríguezDepartamento de Fisiología, Facultad de Farmacia, Universidad Complutense, Madrid, Spain.
César CorbachoDepartamento de Anatomía Patológica, Hospital Universitario Puerta de Hierro-Majadahonda, Madrid, Spain.
Joaquín CarballidoDepartamento de Urología, Hospital Universitario Puerta de Hierro-Majadahonda, Madrid, Spain.
Albino García-SacristánDepartamento de Fisiología, Facultad de Farmacia, Universidad Complutense, Madrid, Spain.
Medardo HernándezDepartamento de Fisiología, Facultad de Farmacia, Universidad Complutense, Madrid, Spain.
Luis RiveraDepartamento de Fisiología, Facultad de Farmacia, Universidad Complutense, Madrid, Spain.
Javier Sáenz-MedinaDepartamento de Urología, Hospital Universitario Puerta de Hierro-Majadahonda, Madrid, Spain.
Dolores PrietoDepartamento de Fisiología, Facultad de Farmacia, Universidad Complutense, Madrid, Spain. Electronic address: dprieto@ucm.es.
Universidad Complutense de Madrid · ESHospital Universitario Puerta de Hierro Majadahonda · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The role of NADPH oxidase (Nox)-derived reactive oxygen species in kidney vascular function has extensively been investigated in the harmful context of oxidative stress in diabetes and obesity-associated kidney disease. Since hydrogen peroxide (H

Indexed as

VasodilationAgedAnimalsArteriesEndothelium, VascularFemaleHumansHydrogen PeroxideKidneyMaleMiddle AgedNADPH Oxidase 2NADPH Oxidase 4Rats, WistarCYBB protein, humanHydrogen PeroxideNADPH Oxidase 2NADPH Oxidase 4NOX4 protein, humanEndothelium-mediated vasodilatationHuman intrarenal arteriesHydrogen peroxideNox2Nox4

Identifiers

PMID30125808
PMCPMC6105769
OpenAlexW2885299959

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.