Evidence map›Paper›PMID 30125729›Full record

ArticleBone2018

Osteoblast derived-neurotrophin‑3 induces cartilage removal proteases and osteoclast-mediated function at injured growth plate in rats.

Yu-Wen Su, Shek Man Chim, Lin Zhou, Mohammadhossein Hassanshahi, Rosa Chung, Chiaming Fan, Yunmei Song, Bruce K Foster, Clive A Prestidge, Yaser Peymanfar and 9 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bone, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
0.9field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 20 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Review
  5. Review
  6. Nervous System-Driven Osseointegration.International journal of molecular sciences · 2022
    Review
  7. Article
  8. [Research progress of Schwann cells regulating bone regeneration].Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery · 2022
    Review
  9. Macrophage-derived neurotrophin-3 promotes heterotopic ossification in rats.Laboratory investigation; a journal of technical methods and pathology · 2020
    Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 6 institutions in 3 countries.

Yu-Wen SuSchool of Pharmacy and Medical Sciences, Sansom Institute for Health Research, University of South Australia, Adelaide, SA 5001, Australia. Electronic address: yu-wen.su@unisa.edu.au.
Shek Man ChimSchool of Pathology and Laboratory Medicine, University of Western Australia, Nedlands, WA 6009, Australia. Electronic address: Shek_Chim@hsdm.harvard.edu.
Lin ZhouSchool of Pathology and Laboratory Medicine, University of Western Australia, Nedlands, WA 6009, Australia. Electronic address: 20463692@student.uwa.edu.au.
Mohammadhossein HassanshahiSchool of Pharmacy and Medical Sciences, Sansom Institute for Health Research, University of South Australia, Adelaide, SA 5001, Australia. Electronic address: mohammadhossein.hassanshahi@unisa.edu.au.
Rosa ChungSchool of Pharmacy and Medical Sciences, Sansom Institute for Health Research, University of South Australia, Adelaide, SA 5001, Australia. Electronic address: rosa.chung@unisa.edu.au.
Chiaming FanSchool of Pharmacy and Medical Sciences, Sansom Institute for Health Research, University of South Australia, Adelaide, SA 5001, Australia.
Yunmei SongSchool of Pharmacy and Medical Sciences, Sansom Institute for Health Research, University of South Australia, Adelaide, SA 5001, Australia. Electronic address: may.song@unisa.edu.au.
Bruce K FosterDepartment of Orthopaedic Surgery, Women's and Children's Hospital, North Adelaide, SA 5006, Australia. Electronic address: bruce.foster@health.sa.gov.au.
Clive A PrestidgeSchool of Pharmacy and Medical Sciences, Sansom Institute for Health Research, University of South Australia, Adelaide, SA 5001, Australia; ARC Centre of Excellence in Convergent Bio-Nano Science and Technology, University of South Australia, Mawson Lakes Campus, Mawson Lakes 5095, Australia. Electronic address: Clive.Prestidge@unisa.edu.au.
Yaser PeymanfarSchool of Pharmacy and Medical Sciences, Sansom Institute for Health Research, University of South Australia, Adelaide, SA 5001, Australia. Electronic address: yaser.peymanfar@mymail.unisa.edu.au.
Qian TangSchool of Pharmacy and Medical Sciences, Sansom Institute for Health Research, University of South Australia, Adelaide, SA 5001, Australia. Electronic address: qian.tang@unisa.edu.au.
Lisa M ButlerUniversity of Adelaide Schools of Medicine and Medical Sciences, South Australian Health and Medical Research Institute, Adelaide, SA, Australia. Electronic address: lisa.butler@adelaide.edu.au.
Stan GronthosUniversity of Adelaide Schools of Medicine and Medical Sciences, South Australian Health and Medical Research Institute, Adelaide, SA, Australia. Electronic address: stan.gronthos@adelaide.edu.au.
Di ChenDepartment of Orthopedic Surgery, Rush University Medical Center, Chicago, IL 60612, USA. Electronic address: di_chen@rush.edu.
Yangli XieState Key Laboratory of Trauma, Burns and Combined Injury, Center of Bone Metabolism and Repair, Institute of Surgery Research, Daping Hospital, Third Military Medical University, Chongqing 400042, China.
Lin ChenState Key Laboratory of Trauma, Burns and Combined Injury, Center of Bone Metabolism and Repair, Institute of Surgery Research, Daping Hospital, Third Military Medical University, Chongqing 400042, China.
Xin-Fu ZhouSchool of Pharmacy and Medical Sciences, Sansom Institute for Health Research, University of South Australia, Adelaide, SA 5001, Australia. Electronic address: xin-fu.zhou@unisa.edu.au.
Jiake XuSchool of Pathology and Laboratory Medicine, University of Western Australia, Nedlands, WA 6009, Australia. Electronic address: jiake.xu@uwa.edu.au.
Cory J XianSchool of Pharmacy and Medical Sciences, Sansom Institute for Health Research, University of South Australia, Adelaide, SA 5001, Australia. Electronic address: cory.xian@unisa.edu.au.
University of South Australia · AUThe University of Western Australia · AUArmy Medical University · CNSouth Australian Health and Medical Research Institute · AURush University Medical Center · USWomen's and Children's Hospital · AU

Funding

The Mechanism through which TGF-Beta Maintains Chondrocytes in Proliferating StagR01AR054465 · NIAMS · UNIVERSITY OF ROCHESTER · PI CHEN, DI · 2007 to 2018
$2.7M
NIAMS NIH HHS R01 AR054465
6 · The paper itself

Abstract

Faulty bony repair causes dysrepair of injured growth plate cartilage and bone growth defects in children; however, the underlying mechanisms are unclear. Recently, we observed the prominent induction of neurotrophin‑3 (NT-3) and its important roles as an osteogenic and angiogenic factor promoting the bony repair. The current study investigated its roles in regulating injury site remodelling. In a rat tibial growth plate drill-hole injury repair model, NT-3 was expressed prominently in osteoblasts at the injury site. Recombinant NT-3 (rhNT-3) systemic treatment enhanced, but NT-3 immunoneutralization attenuated, expression of cartilage-removal proteases (MMP-9 and MMP-13), presence of bone-resorbing osteoclasts and expression of osteoclast protease cathepsin K, and remodelling at the injury site. NT-3 was also highly induced in cultured mineralizing rat bone marrow stromal cells, and the conditioned medium augmented osteoclast formation and resorptive activity, an ability that was blocked by presence of anti-NT-3 antibody. Moreover, NT-3 and receptor TrkC were induced during osteoclastogenesis, and rhNT-3 treatment activated TrkC downstream kinase Erk1/2 in differentiating osteoclasts although rhNT-3 alone did not affect activation of osteoclastogenic transcription factors NF-κB or NFAT in RAW

Indexed as

AnimalsBony CallusCartilage, ArticularCytokinesEnzyme ActivationGrowth PlateHumansMaleMiceNeurotrophin 3NFATC Transcription FactorsNF-kappa BOsteoblastsOsteoclastsOsteogenesisPeptide HydrolasesCytokinesNeurotrophin 3NFATC Transcription FactorsNF-kappa BPeptide HydrolasesRANK LigandReceptor, trkCRNA, MessengerGrowth plate injuryInjury site remodellingNeurotrophic factorsSignal crosstalk

Identifiers

PMID30125729
PMCPMC6550307
OpenAlexW2885051833

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.