Evidence map›Paper›PMID 30125594›Full record

ArticleNeurochemistry international2019

Identification of the benztropine analog [

Michael J Tomlinson, Danielle Krout, Akula Bala Pramod, John R Lever, Amy Hauck Newman, L Keith Henry, Roxanne A Vaughan

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurochemistry international, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.2field-weighted citation impact, top 52% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. ZembrinMolecules (Basel, Switzerland) · 2026
    Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Michael J TomlinsonDepartment of Biomedical Sciences, University of North Dakota School of Medicine and Health Sciences, 1301 North Columbia Road, Grand Forks, ND 58202, United States.
Danielle KroutDepartment of Biomedical Sciences, University of North Dakota School of Medicine and Health Sciences, 1301 North Columbia Road, Grand Forks, ND 58202, United States.
Akula Bala PramodDepartment of Biomedical Sciences, University of North Dakota School of Medicine and Health Sciences, 1301 North Columbia Road, Grand Forks, ND 58202, United States.
John R LeverResearch Service, Harry S. Truman Memorial Veterans' Hospital, Columbia, MO, 65201, United States; Department of Radiology and Radiopharmaceutical Sciences Institute, University of Missouri, Columbia, MO 65211, United States.
Amy Hauck NewmanMedicinal Chemistry Section, National Institute on Drug Abuse - Intramural Research Program, Baltimore, MD 21224, United States.
L Keith HenryDepartment of Biomedical Sciences, University of North Dakota School of Medicine and Health Sciences, 1301 North Columbia Road, Grand Forks, ND 58202, United States. Electronic address: keith.henry@med.und.edu.
Roxanne A VaughanDepartment of Biomedical Sciences, University of North Dakota School of Medicine and Health Sciences, 1301 North Columbia Road, Grand Forks, ND 58202, United States. Electronic address: roxanne.vaughan@med.und.edu.
University of North Dakota · USHarry S. Truman Memorial Veterans' Hospital · USNational Institute on Drug Abuse · US

Funding

Novel Probes for the Monoamine TransportersZIADA000389 · NIDA · NATIONAL INSTITUTE ON DRUG ABUSE · PI NEWMAN, AMY HAUCK · 2009 to 2025
$14.4M
Monoamine Transporter NanoprobesZIADA000610 · NIDA · NATIONAL INSTITUTE ON DRUG ABUSE · PI NEWMAN, AMY HAUCK · 2016 to 2020
$2.5M
Computational and Biochemical Docking of Dopamine Transporter AntagonistsR01DA027845 · NIDA · UNIVERSITY OF NORTH DAKOTA · PI HENRY, LOREN KEITH, VAUGHAN, ROXANNE A · 2010 to 2014
$1.5M
SYNTHETIC STRATEGIES TOWARD THE ELUCIDATION OF CENTRAL MECHANISMS IN THE BEHAVIORZ01DA000389 · NIDA · NATIONAL INSTITUTE ON DRUG ABUSE · PI NEWMAN, AMY HAUCK · 1996 to 2008
$1.3M
Intramural NIH HHS Z01 DA000389Intramural NIH HHS ZIA DA000389Intramural NIH HHS ZIA DA000610NIDA NIH HHS R01 DA027845
6 · The paper itself

Abstract

The dopamine transporter (DAT) is a neuronal membrane protein that is responsible for reuptake of dopamine (DA) from the synapse and functions as a major determinant in control of DA neurotransmission. Cocaine and many psychostimulant drugs bind to DAT and block reuptake, inducing DA overflow that forms the neurochemical basis for euphoria and addiction. Paradoxically, however, some ligands such as benztropine (BZT) bind to DAT and inhibit reuptake but do not produce these effects, and it has been hypothesized that differential mechanisms of binding may stabilize specific transporter conformations that affect downstream neurochemical or behavioral outcomes. To investigate the binding mechanisms of BZT on DAT we used the photoaffinity BZT analog [

Indexed as

Structure-Activity RelationshipBenztropineBinding SitesCocaineDopamineDopamine Plasma Membrane Transport ProteinsDopamine Uptake InhibitorsHumansIodine RadioisotopesBenztropineCocaineDopamineDopamine Plasma Membrane Transport ProteinsDopamine Uptake InhibitorsIodine-125Iodine RadioisotopesBenztropineCocaineMolecular modelingPeptide mappingPhotoaffinity labelingSCAM

Identifiers

PMID30125594
PMCPMC8295913
OpenAlexW2885296674

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.