Evidence map›Paper›PMID 30125493›Full record

ArticleJournal of the American Chemical Society2018

Repurposing Triphenylmethane Dyes to Bind to Trimers Derived from Aβ.

Patrick J Salveson, Sepehr Haerianardakani, Alexander Thuy-Boun, Stan Yoo, Adam G Kreutzer, Borries Demeler, James S Nowick

Erratum issuedOpen access · greenAbstract read
In one paragraph

Article in Journal of the American Chemical Society, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
2.3field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 43 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. Review
  7. Exploring amyloid oligomers with peptide model systems.Current opinion in chemical biology · 2021
    Review
  8. Synthesis and characterization of Ni-doped anatase TiOEnvironmental science and pollution research international · 2021
    Article
  9. The AutoDock suite at 30.Protein science : a publication of the Protein Society · 2021
    Article
  10. Article
  11. Article
  12. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Patrick J SalvesonDepartment of Chemistry , University of California Irvine , Irvine , California 92697-2025 , United States.ORCID 0000-0003-0962-6010
Sepehr HaerianardakaniDepartment of Chemistry , University of California Irvine , Irvine , California 92697-2025 , United States.ORCID 0000-0003-1539-2345
Alexander Thuy-BounDepartment of Chemistry , University of California Irvine , Irvine , California 92697-2025 , United States.ORCID 0000-0002-9841-0758
Stan YooDepartment of Chemistry , University of California Irvine , Irvine , California 92697-2025 , United States.ORCID 0000-0002-8982-7631
Adam G KreutzerDepartment of Chemistry , University of California Irvine , Irvine , California 92697-2025 , United States.ORCID 0000-0002-9724-6298
Borries DemelerDepartment of Biochemistry , University of Texas Health Science Center , San Antonio , Texas 78229-3900 , United States.ORCID 0000-0002-2414-9518
James S NowickDepartment of Chemistry , University of California Irvine , Irvine , California 92697-2025 , United States.ORCID 0000-0002-2273-1029
University of California, Irvine · USThe University of Texas Health Science Center at San Antonio · US

Funding

TISSUE CULTURE---COREP30CA054174 · NCI · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI Robin Jean Leach · 1991 to 2026
$59.1M
Development of an UltraScan Meta-Scheduler for HPC Job SubmissionR01GM120600 · NIGMS · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI Emre H. Brookes, BORRIES DEMELER · 2016 to 2026
$3.6M
Purchase of an Microwave Peptide SynthesizerR01GM097562 · NIGMS · UNIVERSITY OF CALIFORNIA-IRVINE · PI NOWICK, JAMES S · 2012 to 2019
$2.5M
Training Program in Chemical and Structural BiologyT32GM108561 · NIGMS · UNIVERSITY OF CALIFORNIA-IRVINE · PI POULOS, THOMAS L, TOBIAS, DOUGLAS J · 2014 to 2018
$860k
NCI NIH HHS P30 CA054174NIGMS NIH HHS R01 GM097562NIGMS NIH HHS R01 GM120600NIGMS NIH HHS T32 GM108561
6 · The paper itself

Abstract

Soluble oligomers of the β-amyloid peptide, Aβ, are associated with the progression of Alzheimer's disease. Although many small molecules bind to these assemblies, the details of how these molecules interact with Aβ oligomers remain unknown. This paper reports that crystal violet, and other C3 symmetric triphenylmethane dyes, bind to C3 symmetric trimers derived from Aβ

Indexed as

Amyloid beta-PeptidesBinding SitesColoring AgentsTriphenylmethyl CompoundsAmyloid beta-PeptidesColoring AgentstriphenylmethaneTriphenylmethyl Compounds

Identifiers

PMID30125493
PMCPMC6339561
OpenAlexW2888026393

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.