Evidence map›Paper›PMID 30125312›Full record

ArticlePloS one2018

Prognostic significance of CT-determined sarcopenia in patients with advanced gastric cancer.

Jong Soo Lee, Young Saing Kim, Eun Young Kim, Wook Jin

Registry-linked trialOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PloS one, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07163286 (Evaluation and Comparison of Malnutrition and Sarcopenia Risk Using PG-SGA, MUST, Nutriscore, and GLIM Criteria in Cancer Patients Undergoing Chemotherapy), which is not on this map. Cited by 71 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
71citing papers in PubMed, 5 pooled it
9.0field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07163286 active not recruitingnot on this mapstarted 2025, after this paper: background citation

Evaluation and Comparison of Malnutrition and Sarcopenia Risk Using PG-SGA, MUST, Nutriscore, and GLIM Criteria in Cancer Patients Undergoing Chemotherapy

TypeobservationalSponsorÇanakkale Onsekiz Mart UniversityRan2025 to 2026Enrolled200ConditionsNutrition Aspect of Cancer, Sarcopenia, Chemotherapeutic Agent Toxicity
3 · Its place in the literature

Who cites it

71 citing papers in PubMed, 5 syntheses or guidelines pooled it, 118 citations in OpenAlex.

  1. Pooled it
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  6. Feasibility and safety of exercise during chemotherapy in people with gastrointestinal cancers: a pilot study.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2023
    Trial
  7. Body weight loss as a prognostic and predictive factor in previously treated patients with metastatic gastric cancer: post hoc analyses of the randomized phase III TAGS trial.Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association · 2023
    Trial
  8. Article
  9. CT-defined sarcopenia as a predictor of early mortality following hip fracture: a retrospective cohort study.European journal of orthopaedic surgery & traumatology : orthopedie traumatologie · 2026
    Article
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  14. Review
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  17. The Influence of Muscle Morphology on Oncological Outcomes: A Review.Journal of frailty, sarcopenia and falls · 2025
    Review
  18. Article
  19. Article
  20. Article

11 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Jong Soo LeeSchool of Medicine, Gachon University School of Medicine, Incheon, South Korea.ORCID 0000-0002-1125-137X
Young Saing KimDivision of Medical Oncology, Department of Internal Medicine, Gachon University Gil Medical Center, Incheon, South Korea.
Eun Young KimDepartment of Radiology, Gachon University Gil Medical Center, Incheon, South Korea.ORCID 0000-0002-2101-7982
Wook JinLaboratory of Molecular Disease and Cell Regulation, Department of Biochemistry, Gachon University School of Medicine, Incheon, South Korea.
Gachon University · KRGachon University Gil Medical Center · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundSarcopenia, defined as decreased skeletal muscle mass, is prevalent and associated with poor prognosis in various solid tumors. This study aimed to determine the prognostic role of sarcopenia in patients with advanced gastric cancer (AGC).

methodsThis retrospective study consisted of 140 consecutive patients who underwent palliative chemotherapy for AGC. A cross-sectional area of muscle at the level of the third lumbar vertebra (L3) was measured using baseline computed tomography (CT) scans. Sarcopenia was defined as a L3 skeletal muscle index of ≤ 49 cm2/m2 for men and ≤ 31 cm2/m2 for women using Korean-specific cutoffs. We compared the overall survival (OS) and clinical characteristics of patients with and without sarcopenia.

resultsThe median age was 67 years, and 133 (95%) patients had metastatic disease. Sarcopenia was present in 67 patients (47.9%) and was significantly related to male sex (p < 0.001) and low body mass index (p = 0.002). Patients with sarcopenia had a significantly shorter OS than those without sarcopenia (median, 6.8 months vs. 10.3 months, respectively; p = 0.033). In the multivariable analysis, sarcopenia was an independent prognostic factor of poor OS (hazard ratio, 1.51, p = 0.029); no response to chemotherapy (p < 0.001), no second-line chemotherapy (p < 0.001), metastatic sites ≥ 3 (p < 0.001), and low serum albumin level (p = 0.033) were also independent prognostic factors of poor OS.

conclusionSarcopenia, as determined by baseline CT, can be used to predict poor prognosis in AGC patients treated with palliative chemotherapy.

Indexed as

AdultAgedAged, 80 and overAntineoplastic Combined Chemotherapy ProtocolsBody Mass IndexFemaleHumansMaleMiddle AgedMuscle, SkeletalNeoplasm StagingPrognosisProportional Hazards ModelsRetrospective StudiesSarcopeniaSerum AlbuminSerum Albumin

Identifiers

PMID30125312
PMCPMC6101416
OpenAlexW2888575486

What OpenQuestion holds

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LicenceCC BY
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.