Evidence map›Paper›PMID 30125283›Full record

Trial reportPloS one2018

Invasive Streptococcus pneumoniae infection among hospitalized patients in Jingzhou city, China, 2010-2012.

Hui Jiang, Yang Huai, Hui Chen, Timothy M Uyeki, Maoyi Chen, Xuhua Guan, Shali Liu, Youxing Peng, Hui Yang, Jun Luo and 14 more

Open access · goldAbstract readClinical TrialMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Trial report in PloS one, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
0.6field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it, 11 citations in OpenAlex.

  1. Prevalence ofHuman vaccines & immunotherapeutics · 2024
    Pooled it
  2. Article
  3. Review
  4. Article
  5. Article
  6. Review
  7. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

24 authors at 8 institutions in 2 countries.

Hui JiangKey Laboratory of Surveillance and Early-warning on Infectious Disease, Division of Infectious Disease, Chinese Center for Disease Control and Prevention, Beijing, China.
Yang HuaiChina-US Collaborative Program on Emerging and Re-Emerging Infection Disease, Center for Global Health, Centers for Disease Control and Prevention, Beijing, China.
Hui ChenHubei Provincial Center for Disease Control and Prevention, Wuhan, China.
Timothy M UyekiInfluenza Division, National Center for Immunization and Respiratory Diseases, Atlanta, GA, United States of America.
Maoyi ChenJingzhou Center for Disease Control and Prevention, Jingzhou, China.
Xuhua GuanHubei Provincial Center for Disease Control and Prevention, Wuhan, China.
Shali LiuJingzhou Central Hospital, Jingzhou, China.
Youxing PengJingzhou First People's Hospital, Jingzhou, China.
Hui YangJingzhou Second People's Hospital, Jingzhou, China.
Jun LuoJingzhou Maternal and Children's Hospital, Jingzhou, China.
Jiandong ZhengKey Laboratory of Surveillance and Early-warning on Infectious Disease, Division of Infectious Disease, Chinese Center for Disease Control and Prevention, Beijing, China.
Jigui HuangJingzhou Center for Disease Control and Prevention, Jingzhou, China.
Zhibin PengKey Laboratory of Surveillance and Early-warning on Infectious Disease, Division of Infectious Disease, Chinese Center for Disease Control and Prevention, Beijing, China.
Nijuan XiangKey Laboratory of Surveillance and Early-warning on Infectious Disease, Division of Infectious Disease, Chinese Center for Disease Control and Prevention, Beijing, China.
Yuzhi ZhangChina-US Collaborative Program on Emerging and Re-Emerging Infection Disease, Center for Global Health, Centers for Disease Control and Prevention, Beijing, China.
John D KlenaChina-US Collaborative Program on Emerging and Re-Emerging Infection Disease, Center for Global Health, Centers for Disease Control and Prevention, Beijing, China.
Dale J HuChina-US Collaborative Program on Emerging and Re-Emerging Infection Disease, Center for Global Health, Centers for Disease Control and Prevention, Beijing, China.
Jeanette J RaineyChina-US Collaborative Program on Emerging and Re-Emerging Infection Disease, Center for Global Health, Centers for Disease Control and Prevention, Beijing, China.
Xixiang HuoHubei Provincial Center for Disease Control and Prevention, Wuhan, China.
Lin XiaoJingzhou Center for Disease Control and Prevention, Jingzhou, China.
Xuesen XingHubei Provincial Center for Disease Control and Prevention, Wuhan, China.
Faxian ZhanHubei Provincial Center for Disease Control and Prevention, Wuhan, China.
Hongjie YuKey Laboratory of Surveillance and Early-warning on Infectious Disease, Division of Infectious Disease, Chinese Center for Disease Control and Prevention, Beijing, China.
Jay K VarmaChina-US Collaborative Program on Emerging and Re-Emerging Infection Disease, Center for Global Health, Centers for Disease Control and Prevention, Beijing, China.
Chinese Center For Disease Control and Prevention · CNHubei Provincial Center for Disease Control and Prevention · CNJingzhou Central Hospital · CNCenter for Global Health · USCenters for Disease Control and Prevention · USFirst People's Hospital of Jingzhou · CNJingzhou Maternal and Child Health Hospital · CNNational Center for Immunization and Respiratory Diseases · US

Funding

Virology &ImmunologyU19AI051915 · NIAID · NATIONAL CENTER FOR AIDS/STD CONTROL AND PREVENTION · PI SHAO, YIMING · 2002 to 2009
$21.6M
CGH CDC HHS U2G GH000018NIAID NIH HHS U19 AI051915
6 · The paper itself

Abstract

backgroundStreptococcus pneumoniae (Sp) is a leading cause of bacterial pneumonia, meningitis, and sepsis and a major source of morbidity and mortality worldwide. Invasive pneumococcal disease (IPD) is defined as isolation of Sp from a normally sterile site, including blood or cerebrospinal fluid. The aim of this study is to describe outcomes as well as clinical and epidemiological characteristics of hospitalized IPD case patients in central China.

methodsWe conducted surveillance for IPD among children and adults from April 5, 2010 to September 30, 2012, in four major hospitals in Jingzhou City, Hubei Province. We collected demographic, clinical, and outcome data for all enrolled hospitalized patients with severe acute respiratory infection (SARI) or meningitis, and collected blood, urine, and cerebrospinal fluid (CSF) for laboratory testing for Sp infections. Collected data were entered into Epidata software and imported into SPSS for analysis.

resultsWe enrolled 22,375 patients, including 22,202 (99%) with SARI and 173 (1%) with meningitis. One hundred and eighteen (118, 3%) with either SARI or meningitis were Sp positive, 32 (0.8%) from blood/CSF culture, and 87 (5%) from urine antigen testing. Of those 118 patients, 57% were aged ≥65 years and nearly 100% received antibiotics during hospitalization. None were previously vaccinated with 7-valent pneumococcal conjugate vaccine (PCV 7), 23-valent pneumococcal polysaccharide vaccine, or seasonal influenza vaccine. The main serotypes identified were 14, 12, 3, 1, 19F, 4, 5, 9V, 15 and 18C, corresponding to serotype coverage rates of 42%, 63%, and 77% for PCV7, PCV10, and PCV13, respectively.

conclusionsFurther work is needed to expand access to pneumococcal vaccination in China, both among children and potentially among the elderly, and inappropriate use of antibiotics is a widespread and serious problem in China.

Indexed as

HospitalizationAcute DiseaseAdolescentAdultAgedChildChild, PreschoolChinaFemaleHumansMaleMeningitis, BacterialMiddle AgedPneumococcal InfectionsPneumococcal VaccinesRespiratory Tract InfectionsPneumococcal Vaccines

Identifiers

PMID30125283
PMCPMC6101356
OpenAlexW2888011843

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.