Evidence map›Paper›PMID 30125087›Full record

ArticleAnalytical chemistry2018

Identification of Intracellular and Extracellular Metabolites in Cancer Cells Using

Guannan Zhang, Susanna Ahola, Mathilde H Lerche, Ville-Veikko Telkki, Christian Hilty

Abstract read
In one paragraph

Article in Analytical chemistry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed.

  1. Article
  2. Live Metabolomics with NMR.Analytical chemistry · 2026
    Review
  3. UltrafastAnalytical chemistry · 2024
    Article
  4. Review
  5. Measuring Protein-Ligand Binding by Hyperpolarized Ultrafast NMR.Journal of the American Chemical Society · 2024
    Article
  6. A Simulation of the Effects of Diffusion on Hyperpolarized [1-IEEE transactions on bio-medical engineering · 2023
    Article
  7. Ultrafast transverse relaxation exchange NMR spectroscopy.Physical chemistry chemical physics : PCCP · 2022
    Article
  8. A Field-Independent Method for the Rapid Generation of Hyperpolarized [1-Angewandte Chemie (International ed. in English) · 2022
    Article
  9. Article
  10. Article
  11. Application of Relaxation Dispersion of HyperpolarizedAngewandte Chemie (International ed. in English) · 2021
    Article
  12. Article
  13. Ultrafast 2DChemical communications (Cambridge, England) · 2021
    Article
  14. Hyperpolarized NMR Metabolomics at NaturalAnalytical chemistry · 2020
    Article
  15. Article
  16. Article
  17. A Biomimetic Plasmonic Nanoreactor for Reliable Metabolite Detection.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Guannan ZhangDepartment of Chemistry , Texas A&M University , 3255 TAMU, College Station , Texas 77843 , United States.
Susanna AholaNMR Research Unit, Faculty of Science , University of Oulu , P.O. Box 3000, 90014 Oulu , Finland.
Mathilde H LercheDepartment of Electrical Engineering, Center for Hyperpolarization in Magnetic Resonance , Technical University of Denmark , Building 349, DK-2800 Kgs Lyngby , Denmark.
Ville-Veikko TelkkiNMR Research Unit, Faculty of Science , University of Oulu , P.O. Box 3000, 90014 Oulu , Finland.ORCID 0000-0003-0846-6852
Christian HiltyDepartment of Chemistry , Texas A&M University , 3255 TAMU, College Station , Texas 77843 , United States.ORCID 0000-0003-2539-2568

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Ultrafast Laplace NMR (UF-LNMR), which is based on the spatial encoding of multidimensional data, enables one to carry out 2D relaxation and diffusion measurements in a single scan. Besides reducing the experiment time to a fraction, it significantly facilitates the use of nuclear spin hyperpolarization to boost experimental sensitivity, because the time-consuming polarization step does not need to be repeated. Here we demonstrate the usability of hyperpolarized UF-LNMR in the context of cell metabolism, by investigating the conversion of pyruvate to lactate in the cultures of mouse 4T1 cancer cells. We show that

Indexed as

AnimalsCell Line, TumorFemaleLactic AcidMagnetic Resonance SpectroscopyMammary Neoplasms, AnimalMicePyruvic AcidLactic AcidPyruvic Acid

Identifiers

PMID30125087
PMCPMC6168181

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.