ArticleSchizophrenia bulletin2019
Early-Stage Negative Symptom Trajectories and Relationships With 13-Year Outcomes in First-Episode Nonaffective Psychosis.
Article in Schizophrenia bulletin, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
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Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it.
- A systematic review and narrative synthesis of data-driven studies in schizophrenia symptoms and cognitive deficits.Translational psychiatry · 2020Pooled it
- Childhood premorbid adjustment as a marker for 20-year impairments in schizophrenia spectrum disorder: results from the OPUS study.European child & adolescent psychiatry · 2026Trial
- Psychosocial Interventions, Recovery, and Mediating Mechanisms in Schizophrenia-Spectrum Disorders: A Systematic Review and Meta-Analysis of Longitudinal Studies.Brain sciences · 2026Review
- Subclinical and attenuated negative symptoms in the prediction of psychosis in children and adolescents: sample composition matters.European child & adolescent psychiatry · 2026Article
- Persistent negative symptoms in the EULAST cohort: impact on functional outcome.Schizophrenia (Heidelberg, Germany) · 2026Article
- Latent Trajectories of Positive, Negative Symptoms and Functioning in Early Intervention Services for First-Episode Psychosis: A 2-Year Follow-Up Study.Schizophrenia bulletin · 2025Article
- Effectiveness and safety of blonanserin monotherapy for first-episode schizophrenia with and without prominent negative symptoms: A prospective study.World journal of psychiatry · 2025Article
- Attenuated niacin response is associated with a subtype of first-episode drug-naïve psychosis characterized as serious negative symptoms.European archives of psychiatry and clinical neuroscience · 2023Article
- 20-year trajectories of positive and negative symptoms after the first psychotic episode in patients with schizophrenia spectrum disorder: results from the OPUS study.World psychiatry : official journal of the World Psychiatric Association (WPA) · 2023Article
- Longitudinal trajectories in negative symptoms and changes in brain cortical thickness: 10-year follow-up study.The British journal of psychiatry : the journal of mental science · 2023Article
- Cognitive subgroups and the relationships with symptoms, psychosocial functioning and quality of life in first-episode non-affective psychosis: a cluster-analysis approach.Frontiers in psychiatry · 2023Article
- A transdiagnostic approach to negative symptoms: exploring factor structure and negative symptoms in bipolar disorders.Frontiers in psychiatry · 2023Article
- Heterogeneity in Response to MCT and Psychoeducation: A Feasibility Study Using Latent Class Mixed Models in First-Episode Psychosis.Healthcare (Basel, Switzerland) · 2022Article
- Males and females with first episode psychosis present distinct profiles of social cognition and metacognition.European archives of psychiatry and clinical neuroscience · 2022Article
- Reduced learning bias towards the reward context in medication-naive first-episode schizophrenia patients.BMC psychiatry · 2022Article
- Dynamic Interplay Between Insight and Persistent Negative Symptoms in First Episode of Psychosis: A Longitudinal Study.Schizophrenia bulletin · 2022Article
- Duration of Untreated Disorder and Cannabis Use: An Observational Study on a Cohort of Young Italian Patients Experiencing Psychotic Experiences and Dissociative Symptoms.International journal of environmental research and public health · 2021Observational
- The Latent Structure of Negative Symptoms in Individuals With Attenuated Psychosis Syndrome and Early Psychosis: Support for the 5 Consensus Domains.Schizophrenia bulletin · 2021Article
- Heterogeneity of Outcomes and Network Connectivity in Early-Stage Psychosis: A Longitudinal Study.Schizophrenia bulletin · 2021Article
- Exploring Risk and Resilient Profiles for Functional Impairment and Baseline Predictors in a 2-Year Follow-Up First-Episode Psychosis Cohort Using Latent Class Growth Analysis.Journal of clinical medicine · 2020Article
Corrections and comments
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Negative symptoms are a key treatment target in early psychosis intervention. There is a paucity of research examining longitudinal course of negative symptoms across the initial years of treatment for first-episode psychosis using individual-based trajectory analysis. No study has been conducted investigating differential relationships of early-stage negative symptom trajectories with long-term distal outcomes. This study examined patterns and baseline predictors of negative symptom trajectories over the first 3 years of treatment in 138 patients aged 18-55 years presenting with first-episode nonaffective psychosis, using latent class growth analysis based on symptom ratings measured at 4 different time points (baseline, 1, 2, and 3 years). We further explored prospective relationships of identified trajectory classes with functional and negative symptom outcomes at 13-year follow-up. Our results revealed 3 distinct negative symptom trajectories including minimal-stable (59.6%), mild-stable (29.4%), and high-increasing (11.0%) trajectories. Poorer premorbid adjustment, more severe global cognitive impairment, and depressive symptoms at baseline were found to predict high-increasing trajectory. Among 3 trajectory classes, patients in high-increasing trajectory had the worst functional and negative symptom outcomes at 13-year follow-up, with post hoc analyses demonstrating significant outcome differences between high-increasing and minimal-stable trajectories. Our findings thus affirm a heterogeneous course of negative symptoms in first-episode psychosis and indicate that early-stage negative symptom trajectories are critically associated with long-term outcomes. Patients displaying persistently high negative symptom levels in the initial 3 years of treatment may represent a specific subgroup who necessitates an extended period of early intervention specifically targeting at negative symptoms to promote early functional recovery.
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