Evidence map›Paper›PMID 30124794›Full record

ArticleBioinformatics (Oxford, England)2019

Genome Detective: an automated system for virus identification from high-throughput sequencing data.

Michael Vilsker, Yumna Moosa, Sam Nooij, Vagner Fonseca, Yoika Ghysens, Korneel Dumon, Raf Pauwels, Luiz Carlos Alcantara, Ewout Vanden Eynden, Anne-Mieke Vandamme and 2 more

Open access · hybridAbstract read
In one paragraph

Article in Bioinformatics (Oxford, England), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 283 papers.

0numbers the graph read from it
0cells of the map it votes in
283citing papers in PubMed
23.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

283 citing papers in PubMed, 427 citations in OpenAlex.

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223 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 5 countries.

Michael VilskerEmweb bvba, Herent, Belgium.
Yumna MoosaKwaZulu-Natal Research Innovation and Sequencing Platform (KRISP), School of Laboratory Medicine and Medical Sciences, Nelson R Mandela School of Medicine, College of Health Sciences, University of KwaZulu-Natal, Durban, South Africa.
Sam NooijThe Dutch National Institute for Public Health and the Environment (RIVM), Bilthoven, The Netherlands.
Vagner FonsecaKwaZulu-Natal Research Innovation and Sequencing Platform (KRISP), School of Laboratory Medicine and Medical Sciences, Nelson R Mandela School of Medicine, College of Health Sciences, University of KwaZulu-Natal, Durban, South Africa.
Yoika GhysensEmweb bvba, Herent, Belgium.
Korneel DumonEmweb bvba, Herent, Belgium.
Raf PauwelsEmweb bvba, Herent, Belgium.
Luiz Carlos AlcantaraInstituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil.
Ewout Vanden EyndenKU Leuven, Department of Microbiology and Immunology, Rega Institute for Medical Research, Clinical and Epidemiological Virology, Leuven, Belgium.
Anne-Mieke VandammeKU Leuven, Department of Microbiology and Immunology, Rega Institute for Medical Research, Clinical and Epidemiological Virology, Leuven, Belgium.
Koen DeforcheEmweb bvba, Herent, Belgium.
Tulio de OliveiraKwaZulu-Natal Research Innovation and Sequencing Platform (KRISP), School of Laboratory Medicine and Medical Sciences, Nelson R Mandela School of Medicine, College of Health Sciences, University of KwaZulu-Natal, Durban, South Africa.
Emweb (Belgium) · BERega Institute for Medical Research · BEUniversidade Federal de Minas Gerais · BRUniversity of KwaZulu-Natal · ZANational Institute for Public Health and the Environment · NL

Funding

H3ABioNet: informatics solutions for H3AfricaU24HG006941 · NHGRI · UNIVERSITY OF CAPE TOWN · PI MULDER, NICOLA · 2017 to 2021
$12.9M
NHGRI NIH HHS U24 HG006941
6 · The paper itself

Abstract

summaryGenome Detective is an easy to use web-based software application that assembles the genomes of viruses quickly and accurately. The application uses a novel alignment method that constructs genomes by reference-based linking of de novo contigs by combining amino-acids and nucleotide scores. The software was optimized using synthetic datasets to represent the great diversity of virus genomes. The application was then validated with next generation sequencing data of hundreds of viruses. User time is minimal and it is limited to the time required to upload the data. AVAILABILITY AND IMPLEMENTATION: Available online: http://www.genomedetective.com/app/typingtool/virus/. SUPPLEMENTARY INFORMATION: Supplementary data are available at Bioinformatics online.

Indexed as

High-Throughput Nucleotide SequencingDrug Delivery SystemsGenome, ViralSequence Analysis, DNASoftwareViruses

Identifiers

PMID30124794
PMCPMC6524403
OpenAlexW2887749901

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.