SynthesisAnnals of behavioral medicine : a publication of the Society of Behavioral Medicine2018
N-of-1 Randomized Intervention Trials in Health Psychology: A Systematic Review and Methodology Critique.
Synthesis in Annals of behavioral medicine : a publication of the Society of Behavioral Medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed.
- Power analysis for idiographic (within-subject) clinical trials: Implications for treatments of rare conditions and precision medicine.Behavior research methods · 2023Article
- N-of-1 trials: The epitome of personalized medicine?Journal of clinical and translational science · 2023Article
- An R Shiny App for a Chronic Lower Back Pain Study, Personalized N-of-1 Trial.Harvard data science review · 2022Article
- A scoping review of randomized trials assessing the impact of n-of-1 trials on clinical outcomes.PloS one · 2022Article
- Personalized (N-of-1) Trials for Patient-Centered Treatments of Multimorbidity.Harvard data science review · 2022Article
- Single case designs for early phase behavioral translational research in health psychology.Health psychology : official journal of the Division of Health Psychology, American Psychological Association · 2021Article
- Establishment of an International Collaborative Network for N-of-1 Trials and Single-Case Designs.Contemporary clinical trials communications · 2021Article
- Article
- An N-of-1 study of daily alcohol consumption following minimum unit pricing implementation in Scotland.Addiction (Abingdon, England) · 2021Observational
- Experimental Designs to Optimize Treatments for Individuals: Personalized N-of-1 Trials.JAMA pediatrics · 2021Article
- Innovative methods for observing and changing complex health behaviors: four propositions.Translational behavioral medicine · 2021Review
- Octopus Watch Fosters Family Resilience by Enhancing Occupational Engagement for Children with Spina Bifida and/or Hydrocephalus: Pilot Study.International journal of environmental research and public health · 2020Article
- Precision Health: The Role of the Social and Behavioral Sciences in Advancing the Vision.Annals of behavioral medicine : a publication of the Society of Behavioral Medicine · 2020Article
- Personal preferences for Personalised Trials among patients with chronic diseases: an empirical Bayesian analysis of a conjoint survey.BMJ open · 2020Article
- Investigating the Temporal Relationships between Symptoms and Nebuliser Adherence in People with Cystic Fibrosis: A Series of N-of-1 Observations.Healthcare (Basel, Switzerland) · 2020Article
- ImpulsePal: The systematic development of a smartphone app to manage food temptations using intervention mapping.Digital healthArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
Background: Single-patient, multiple cross-over designs (N-of-1 or single-case randomized clinical trials) with systematic data collection on treatment effects may be useful for increasing the precision of treatments in health psychology. Purposes: To assess the quality of the methods and statistics, describe interventions and outcomes, and explore the heterogeneity of treatment effect of health psychology N-of-1 trials. Methods: We conducted a systematic review of N-of-1 trials from electronic database inception through June 1, 2015. Potentially relevant articles were identified by searching the biomedical electronic databases Ovid, MEDLINE, EMBASE, all six databases in the Cochrane Library, CINAHL, and PsycINFO, and conference proceedings, dissertations, ongoing studies, Open Grey, and the New York Academy's Grey Literature Report. Studies were included if they had health behavior or psychological outcomes and the order of interventions was randomized. We abstracted study characteristics and analytic methods and used the Consolidated Standards of Reporting Trials extension for reporting N-of-1 trials as a quality checklist. Results: Fifty-four N-of-1 trial publications composed of 1,193 participants were included. Less than half of these (36%) reported adequate information to calculate the heterogeneity of treatment effect. Nearly all (90%) provided some quantitative information to determine the superior treatment; 79% used an a priori statistical cutoff, 12% used a graph, and 10% used a combination. Conclusions: N-of-1 randomized trials could be the next major advance in health psychology for precision therapeutics. However, they must be conducted with more methodologic and statistical rigor and must be transparently and fully reported.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.