Evidence map›Paper›PMID 30124355›Full record

ArticleJournal of clinical and experimental neuropsychology2018

Intraindividual variability in neurocognitive performance: No influence due to HIV status or self-reported effort.

Andrew J Levine, Eileen Martin, Cynthia A Munro, Ned Sacktor, Steve Horvath, James T Becker, Multicenter AIDS Cohort Study–Neuropsychology Working Group

Abstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of clinical and experimental neuropsychology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
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  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Andrew J Levinea Department of Neurology , David Geffen School of Medicine at the University of California Los Angeles , Los Angeles , CA , USA.
Eileen Martinb Department of Psychiatry , Rush University Medical Center , Chicago , IL , USA.
Cynthia A Munroc Departments of Psychiatry and Neurology , Johns Hopkins University School of Medicine , Baltimore , MD , USA.
Ned Sacktord Department of Neurology , Johns Hopkins University School of Medicine , Baltimore , MD , USA.
Steve Horvathe Departments of Human Genetics and Biostatistics , David Geffen School of Medicine at the University of California Los Angeles , Los Angeles , CA , USA.
James T Beckerf Departments of Psychiatry, Neurology, and Psychology , University of Pittsburgh , Pittsburgh , PA , USA.
Multicenter AIDS Cohort Study–Neuropsychology Working Group

Funding

NATURAL HISTORY OF AIDS IN HOMOSEXUAL MENU01AI035040 · NIAID · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI DETELS, ROGER, MARTINEZ-MAZA, OTONIEL · 1993 to 2018
$75.2M
University of Pittsburgh Multicenter AIDS Cohort Study (MACS)U01AI035041 · NIAID · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI MARTINSON, JEREMY JAMES, RINALDO, CHARLES R · 1993 to 2018
$71.4M
MULTICENTER AIDS COHORT STUDYU01AI035039 · NIAID · NORTHWESTERN UNIVERSITY AT CHICAGO · PI WOLINSKY, STEVEN M · 1993 to 2018
$66.4M
Multicenter Aids Cohort Study- Part B (Baltimore Site)U01AI035042 · NIAID · JOHNS HOPKINS UNIVERSITY · PI BROWN, TODD T, MARGOLICK, JOSEPH B. · 1993 to 2018
$61.5M
Institute for Clinical and Translational ResearchUL1TR001079 · NCATS · JOHNS HOPKINS UNIVERSITY · PI FORD, DANIEL ERNEST · 2013 to 2017
$60.1M
METHODOLOGICAL EXPERTISE IN INTREPRETING MACS DATAU01AI035043 · NIAID · JOHNS HOPKINS UNIVERSITY · PI JACOBSON, LISA P · 1993 to 2011
$26.9M
Center for the Analysis & Management of the Multicenter AIDS Cohort StudyUM1AI035043 · NIAID · JOHNS HOPKINS UNIVERSITY · PI D'SOUZA, GYPSYAMBER, JACOBSON, LISA P · 2012 to 2018
$20.7M
Pathways to HIV-Associated Neurocognitive Disorders: A Systems Biology ApproachR01DA030913 · NIDA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI HORVATH, STEVE, LEVINE, ANDREW J · 2010 to 2014
$1.5M
Cross-tissue study of an accelerated epigenetic aging mechanism caused by HIVR21AG046954 · NIA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI HORVATH, STEVE, LEVINE, ANDREW J · 2015 to 2016
$424k
Causes and consequences of suboptimal cognitive effort in the MACSR03NS110476 · NINDS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI LEVINE, ANDREW J · 2018 to 2019
$156k
NCATS NIH HHS UL1 TR001079NIAID NIH HHS U01 AI035039NIAID NIH HHS U01 AI035040NIAID NIH HHS U01 AI035041NIAID NIH HHS U01 AI035042NIAID NIH HHS U01 AI035043NIAID NIH HHS UM1 AI035043NIA NIH HHS R21 AG046954NIDA NIH HHS R01 DA030913NINDS NIH HHS R03 NS110476
6 · The paper itself

Abstract

introductionHIV-associated neurocognitive disorders (HAND) are estimated to affect approximately 50% of infected individuals at any one time. Dispersion, a type of intraindividual variability in neurocognitive test performance, has been identified as a potential behavioral marker of HAND; however, the specificity of dispersion to HAND and how it is influenced by participant effort when taking neurocognitive tests remain unclear.

methodData were analyzed from 996 (474 HIV-, 522 HIV+) men enrolled in the Multicenter AIDS Cohort Study (MACS). Dispersion was calculated based on the standard deviation of an individual's test scores within a single assessment. Effort was determined using the Visual Analogue Effort Scale. Predictors of dispersion were determined using stepwise linear regression. Dispersion was compared between the HIV serostatus groups using analysis of covariance (ANCOVA), considering demographic and psychosocial variables that differed between the groups.

resultsContrary to our hypothesis, dispersion was not influenced by effort. Instead, poorer neurocognitive ability and race were the sole predictors of dispersion. Dispersion did not differ between the serostatus groups.

conclusionsOur results indicate that dispersion is a valid indicator of neurocognitive dysfunction that is not due to suboptimal effort; however, it is not specific to HIV and is therefore of limited utility as a behavioral marker of HIV-related neurocognitive impairment.

Indexed as

Energy MetabolismIndividualityAdultAIDS Dementia ComplexCognitionCohort StudiesDepressionEthnicityHIV SeropositivityHumansMaleMiddle AgedPsychomotor PerformanceSelf ReportDispersionHIV-associated neurocognitive disordersneuroHIVsuboptimal effortvisual analogue scale

Identifiers

PMID30124355
PMCPMC6294568

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.