ReviewBMC biology2018
Horizons in the evolution of aging.
Review in BMC biology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 121 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
121 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- No evidence for a trade-off between reproduction and survival in a meta-analysis across birds.eLife · 2025Pooled it
- Physical Activity on Telomere Length as a Biomarker for Aging: A Systematic Review.Sports medicine - open · 2022Pooled it
- A conserved post-maturity imbalance between housekeeping and integrative genome activity in aging.GeroScience · 2026Article
- LINE-1 CpG methylation in canine blood and cortical DNA tracks epigenetic changes with age.GeroScience · 2026Article
- Histological aging signatures for monitoring tissue-specific aging and disease.Nature medicine · 2026Article
- Evolutionary genetics of ageing.Nature reviews. Genetics · 2026Review
- Exercise attenuates obesity-related cognitive and sleep-circadian dysfunctions by attenuating neuroinflammation via JAK/STAT in sex and age specific manner.International journal of obesity (2005) · 2026Article
- The ageing holobiont: crosstalk between telomere dynamics, oxidative stress and the gut microbiome.Biological reviews of the Cambridge Philosophical Society · 2026Review
- Review
- Relationship Between Age, Auditory Performance, and Quality of Life in Middle-Aged and Older Cochlear Implant Users.Journal of the American Academy of Audiology · 2026Article
- Aryl Hydrocarbon Receptor Signaling in Aging: A Key Modulator of Brain Homeostasis.Molecular neurobiology · 2026Review
- Article
- Sex- and Age-Specific Inverted U-Shaped Links between Dietary Iron Intake and Serum α‑Klotho in Chinese Adults.Biological trace element research · 2026Article
- Evolution of Senescence by Damage Accumulation That Accelerates With Age Throughout an Organism's Lifespan.Ecology and evolution · 2026Article
- Article
- Review
- The Evolutionary Misfit: Evolution, Epigenetics, and the Rise of Non-Communicable Diseases.Epigenomes · 2025Review
- Distribution Analysis of the Lifespan Trait in Drosophila.International journal of molecular sciences · 2025Article
- Cognition, Physical Performance, and Fall-Related Mobility Outcomes in Healthy Older Adults: A Cross-Sectional Study.Sports (Basel, Switzerland) · 2025Article
- Reporting quality, effect sizes, and biases for aging interventions: a methodological appraisal of the DrugAge database.npj aging · 2025Article
61 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Between the 1930s and 50s, evolutionary biologists developed a successful theory of why organisms age, firmly rooted in population genetic principles. By the 1980s the evolution of aging had a secure experimental basis. Since the force of selection declines with age, aging evolves due to mutation accumulation or a benefit to fitness early in life. Here we review major insights and challenges that have emerged over the last 35 years: selection does not always necessarily decline with age; higher extrinsic (i.e., environmentally caused) mortality does not always accelerate aging; conserved pathways control aging rate; senescence patterns are more diverse than previously thought; aging is not universal; trade-offs involving lifespan can be 'broken'; aging might be 'druggable'; and human life expectancy continues to rise but compressing late-life morbidity remains a pressing challenge.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.