ArticlePulmonary circulation
Cardiopulmonary remodeling in fattened beef cattle: a naturally occurring large animal model of obesity-associated pulmonary hypertension with left heart disease.
Article in Pulmonary circulation. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Association of Visual Heart Score with Gross Lung Pathology and Histology of Hepatic and Cardiopulmonary Tissues in Cattle at Harvest.Animals : an open access journal from MDPI · 2026Article
- Monensin intoxication due to intraruminal boluses in beef cattle: retrospective analysis of 7 outbreaks.Brazilian journal of veterinary medicine · 2025Article
- A bovine model of hypoxia-induced pulmonary hypertension reveals a gradient of immune and matrisome response with a complement signature found in circulation.American journal of physiology. Cell physiology · 2024Article
- Genetic parameters for pulmonary arterial pressure, yearling performance, and carcass ultrasound traits in Angus cattle.Journal of animal science · 2023Article
- Variance component estimates, phenotypic characterization, and genetic evaluation of bovine congestive heart failure in commercial feeder cattle.Frontiers in genetics · 2023Article
- Animal models of pulmonary hypertension due to left heart disease.Animal models and experimental medicine · 2022Review
- Understanding the Pathobiology of Pulmonary Hypertension Due to Left Heart Disease.Circulation research · 2022Review
- Association ofF1000Research · 2022Article
- Retrospective analysis of cohort risk factors and feeding phase timing associated with noninfectious heart disease deaths in U.S. feedlot cattle.Translational animal science · 2021Article
- Phenotypic relationships between heart score and feed efficiency, carcass, and pulmonary arterial pressure traits.Translational animal science · 2020Article
- Characterizing the impact of altitude and finishing system on mean pulmonary arterial pressure and carcass characteristics in Angus cattle.Translational animal science · 2019Article
- Investigation of congestive heart failure in beef cattle in a feedyard at a moderate altitude in western Nebraska.Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc · 2019Article
- Evaluation ofF1000Research · 2019Article
- Echocardiographic Changes Related to Pulmonary Hypertension in Preweaned Dairy Calves With Bronchopneumonia: A Case-Control Study in Commercial Dairy Farms.Journal of veterinary internal medicineArticle
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Authors and funding
12 authors.
Funding
Abstract
The obesity epidemic in developed societies has led to increased cardiovascular diseases including pulmonary hypertension associated with left heart disease (PH-LHD), the largest and fastest-growing class of PH. Similar to obese humans, PH and heart failure (HF) are increasingly recognized in North American fattened beef cattle. We hypothesized that PH and HF in fattened beef cattle are novel, phenotypically distinct manifestations of bovine PH arising from left ventricular (LV) dysfunction similar to obesity-related PH-LHD in humans. We conducted a semi-quantitative histopathological assessment of cardiopulmonary tissues obtained from fattened beef cattle suffering end-stage HF compared to asymptomatic cattle of equivalent age undergoing the same fattening regimens. In HF animals we observed significant LV fibrosis, abundant cardiac adipose depots, coronary artery injury, and pulmonary venous remodeling recapitulating human obesity-related PH-LHD. Additionally, striking muscularization, medial hypertrophy, adventitial fibrosis, and vasa vasorum hyperplasia in the pulmonary arterial circulation were associated with sequela of pathologic right ventricular (RV) remodeling suggesting combined pulmonary venous and arterial hypertension. The association between obesity, pathologic cardiopulmonary remodeling, and HF in fattened beef cattle appears to recapitulate the complex pathophysiology of obesity-associated PH-LHD in humans. This novel, naturally occurring, and large animal model may provide mechanistic and translational insights into human disease.
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