Evidence map›Paper›PMID 30123920›Full record

ArticleClinical and translational medicine2018

Biobank integration of large-scale clinical and histopathology melanoma studies within the European Cancer Moonshot Lund Center.

Johan Malm, Yutaka Sugihara, Marcell Szasz, Ho Jeong Kwon, Henrik Lindberg, Roger Appelqvist, György Marko-Varga

Abstract read
In one paragraph

Article in Clinical and translational medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

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  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Johan MalmDepartment of Translational Medicine, Section for Clinical Chemistry, Lund University, Skåne University Hospital Malmö, 205 02, Malmö, Sweden. johan.malm@med.lu.se.
Yutaka SugiharaClinical Protein Science & Imaging, Biomedical Center, Dept. of Biomedical Engineering, Lund University, BMC C13, 221 84, Lund, Sweden.
Marcell SzaszClinical Protein Science & Imaging, Biomedical Center, Dept. of Biomedical Engineering, Lund University, BMC C13, 221 84, Lund, Sweden.
Ho Jeong KwonClinical Protein Science & Imaging, Biomedical Center, Dept. of Biomedical Engineering, Lund University, BMC C13, 221 84, Lund, Sweden.
Henrik LindbergClinical Protein Science & Imaging, Biomedical Center, Dept. of Biomedical Engineering, Lund University, BMC C13, 221 84, Lund, Sweden.
Roger AppelqvistClinical Protein Science & Imaging, Biomedical Center, Dept. of Biomedical Engineering, Lund University, BMC C13, 221 84, Lund, Sweden.
György Marko-VargaClinical Protein Science & Imaging, Biomedical Center, Dept. of Biomedical Engineering, Lund University, BMC C13, 221 84, Lund, Sweden.

Funding

Fru Berta Kamprads Stiftelse Melanoma Cancer MoonshotNational Research Foundation of Korea 2016K2A9A1A03904900
6 · The paper itself

Abstract

We present the Cancer Moonshot clinical project located at the European center in Lund. Here, tissue and blood samples have been collected and stored in a large-scale biobank. Multiple clinical centers around the world are participating and tissue and blood samples are sent to the European Cancer Moonshot Lund Center that acts as the clinical hub. Our center has been developed to generate and build large-scale biostorage archives of patient melanoma samples, which is then combined with a histopathological capability to characterize the patient tumours. Such a large-scale clinical sample processing initiative has begun with the aim of creating high-end histopathology indexing with database computational power and including proteogenomic analysis. The biobank at Lund has become an important resource in clinical research worldwide. Following suite, several national health programs are being initiated with the aim of also building large-scale biobank storages with a wealth of high-quality patient samples. In our Cancer Moonshot R&D activities, samples in the biobanks and the data derived from these samples are being used to build an understanding of disease presentation and using this information to move towards 'Big Data' proteogenomic and mass spectrometry imaging studies. Additionally, we report here a sample processing workflow that has been adapted to a fully-automated biobank processing strategy for large-scale studies.

Identifiers

PMID30123920
PMCPMC6098996

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.