ArticleeNeuro
Central Compensation in Auditory Brainstem after Damaging Noise Exposure.
Article in eNeuro. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 51 papers.
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Who cites it
51 citing papers in PubMed, 70 citations in OpenAlex.
- Developmental Trajectory of Auditory Brainstem Deficits in a Mouse Model of Fetal Alcohol Spectrum Disorders.Developmental neurobiology · 2026Article
- Comparing physiological signatures of synaptopathic noise exposure and carboplatin-induced inner-hair-cell dysfunction in chinchillas.Hearing research · 2026Article
- Temporal dynamics of neuroplasticity and neurodegeneration in the central auditory system following noise-induced hearing loss: a multimodal imaging and histological study.Acta neuropathologica communications · 2026Article
- Potential Risk for Hearing from Prolonged Exposure to Sound at Conversation Levels.Audiology research · 2026Article
- Differentiating the Physiological Signatures of Cochlear Synaptopathy and Inner Hair Cell Damage in a Chinchilla Model.bioRxiv : the preprint server for biology · 2026Article
- Altered folate metabolism disrupts auditory function from neonatal vocalizations to adult perceptual precision.Journal of neurodevelopmental disorders · 2026Article
- Increased vulnerability to noise exposure of low spontaneous rate type 1C spiral ganglion neuron synapses with inner hair cells.Hearing research · 2026Article
- Tinnitus and occupational noise exposure among informal generator technicians in Nigeria: A pilot cohort study.PLOS global public health · 2026Article
- L-type calcium channel modulation reveals the relationship between neuronal synchrony and hyperactivity in the inferior colliculus following noise-induced hearing loss.Scientific reports · 2025Article
- Brain Connectivity, Neural Networks, and Resilience in Aging and Neurodegeneration.The American journal of pathology · 2025Review
- Effects of Noise Stress on Neuronal Activation in Rat Auditory Pathway-Related Brain Regions.Diagnostics (Basel, Switzerland) · 2025Article
- Electrophysiological Evidence of Early Auditory Dysfunction in Personal Listening Device Users: Insights from ABR with Ipsilateral Masking.Diagnostics (Basel, Switzerland) · 2025Article
- A Single Dose of AC102 Reverts Tinnitus by Restoring Ribbon Synapses in Noise-Exposed Mongolian Gerbils.International journal of molecular sciences · 2025Article
- The Auditory Brainstem Response Diagnoses Alzheimer-Like Disease in the 5xFAD Mouse Model.eNeuro · 2025Article
- Auditory evoked-potential abnormalities in a mouse model of 22q11.2 Deletion Syndrome and their interactions with hearing impairment.Translational psychiatry · 2025Article
- Resistance to age-related hearing loss in the echolocating big brown bat (Proceedings. Biological sciences · 2024Article
- Effects of Age on Responses of Principal Cells of the Mouse Anteroventral Cochlear Nucleus in Quiet and Noise.eNeuro · 2024Article
- Auditory brainstem response audiometry in tauopathy mouse model of human Alzheimer's disease.JASA express letters · 2024Article
- Sound elicits stereotyped facial movements that provide a sensitive index of hearing abilities in mice.Current biology : CB · 2024Article
- Article
Corrections and comments
- Erratum issued
Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
Noise exposure is one of the most common causes of hearing loss and peripheral damage to the auditory system. A growing literature suggests that the auditory system can compensate for peripheral loss through increased central neural activity. The current study sought to investigate the link between noise exposure, increases in central gain, synaptic reorganization, and auditory function. All axons of the auditory nerve project to the cochlear nucleus, making it a requisite nucleus for sound detection. As the first synapse in the central auditory system, the cochlear nucleus is well positioned to respond plastically to loss of peripheral input. To investigate noise-induced compensation in the central auditory system, we measured auditory brainstem responses (ABRs) and auditory perception and collected tissue from mice exposed to broadband noise. Noise-exposed mice showed elevated ABR thresholds, reduced ABR wave 1 amplitudes, and spiral ganglion neuron loss. Despite peripheral damage, noise-exposed mice were hyperreactive to loud sounds and showed nearly normal behavioral sound detection thresholds. Ratios of late ABR peaks (2-4) relative to the first ABR peak indicated that brainstem pathways were hyperactive in noise-exposed mice, while anatomical analysis indicated there was an imbalance between expression of excitatory and inhibitory proteins in the ventral cochlear nucleus. The results of the current study suggest that a reorganization of excitation and inhibition in the ventral cochlear nucleus may drive hyperactivity in the central auditory system. This increase in central gain can compensate for peripheral loss to restore some aspects of auditory function.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.