ReviewCurrent opinion in behavioral sciences2018
Apathy in Alzheimer's disease.
Review in Current opinion in behavioral sciences, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 66 papers, 7 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
66 citing papers in PubMed, 7 syntheses or guidelines pooled it.
- Apathy Associated with Alzheimer's Disease.Current Alzheimer research · 2024Pooled it
- Anxiety and depression in Alzheimer's disease: a systematic review of pathogenetic mechanisms and relation to cognitive decline.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2022Pooled it
- Cerebral Volumetric Correlates of Apathy in Alzheimer's Disease and Cognitively Normal Older Adults: Meta-Analysis, Label-Based Review, and Study of an Independent Cohort.Journal of Alzheimer's disease : JAD · 2022Pooled it
- Brain mechanisms underlying neuropsychiatric symptoms in Alzheimer's disease: a systematic review of symptom-general and -specific lesion patterns.Molecular neurodegeneration · 2021Pooled it
- Apathy as a Risky Neuropsychiatric Syndrome of Progression From Normal Aging to Mild Cognitive Impairment and Dementia: A Systematic Review and Meta-Analysis.Frontiers in psychiatry · 2021Pooled it
- Amphetamine Use in the Elderly: A Systematic Review of the Literature.Current neuropharmacology · 2020Pooled it
- Unmet Needs in Pharmacological Treatment of Apathy in Alzheimer's Disease: A Systematic Review.Frontiers in pharmacology · 2019Pooled it
- Measuring Apathy in Alzheimer's Disease in the Apathy in Dementia Methylphenidate Trial 2 (ADMET 2): A Comparison of Instruments.The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry · 2021Trial
- Bupropion for the Treatment of Apathy in Alzheimer Disease: A Randomized Clinical Trial.JAMA network open · 2020Trial
- Associations between apathy and global cognition in a 5-year follow-up of individuals with Alzheimer's disease.Journal of neuropsychology · 2026Article
- Working Memory Deficits in Hippocampal Amnesia are Associated with Apathy.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- On the relationships between apathy, depression and anhedonia.Journal of neurology, neurosurgery, and psychiatry · 2026Article
- Lecanemab Reduces Neuropsychiatric Symptoms and Related Regional Brain Amyloid Load in Early Alzheimer's Disease: A Preliminary Prospective Study.CNS neuroscience & therapeutics · 2026Article
- Overactive Neuronal eEF2K/eEF2 signaling is associated with cognitive impairment and apathy-like behavior.Molecular psychiatry · 2026Article
- Development and Validation of Machine Learning Models for Predicting Early Cognitive Decline Using Home Sensor-Derived Behavioral Data: Sensors in-Home for Elder Wellbeing (SINEW) Cohort Study.JMIR research protocols · 2026Article
- Psychometric Properties of the Greek Apathy Evaluation Scale Clinician Version (AES-C) in MCI Patients and Cognitively Healthy Older Adults.Behavioral sciences (Basel, Switzerland) · 2026Article
- Suppression of neuronal eEF2K alleviates cognitive deficits and apathy-like behavior in APP/PS1 AD model mice.Research square · 2026Article
- The role of diet in moderating the relationship between symptoms of depression and brain amyloid load.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Exploring apathy components and their relationship in cognitive decline: insights from a network cross-sectional study.BMC psychology · 2025Article
- Self- versus caregiver-reported apathy across neurological disorders.Brain communications · 2025Article
6 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
Apathy is the most common neuropsychiatric symptom in patients with Alzheimer's disease (AD). The presence of apathy has been related to greater caregiver distress, decreased quality of life, and increased morbidity. Here we review the most recent studies on this neuropsychiatric syndrome, focusing on prevalence, impact on quality of life, behavioural and neuroimaging studies, and treatment options. The results of some investigations on the behavioural and neuroanatomical profile of apathy in AD point to a role of frontostriatal circuits, specifically involving the anterior cingulate cortex. However, small and heterogeneous samples, lack of control for disease severity, and non-specific apathy scales complicate interpretation of results. Future studies might benefit from studying multiple dimensions of apathy within conceptual frameworks which allow for a deconstruction of underlying mechanisms.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.