ReviewEye and vision (London, England)2018
The retinal function imager and clinical applications.
Review in Eye and vision (London, England), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed, 15 citations in OpenAlex.
- Comparative Assessment of Retinal Blood Flow Velocity Changes Following Brimonidine and Brinzolamide Administration Using Retinal Function Imaging.Translational vision science & technology · 2022Trial
- Intraday and Interday Repeatability of Laser Speckle Contrast Imaging for Ocular Blood Flow Measurement in Healthy Subjects.Translational vision science & technology · 2026Article
- Regional and Layer Specific Retinal Capillary Red Blood Cell Velocimetry in Healthy Human Subjects.Translational vision science & technology · 2025Observational
- Measurement of retinal blood flow precision in the human eye with multimodal adaptive optics imaging.Biomedical optics express · 2024Article
- Assessment of Blood Flow Velocity in Retinal Vasculitis Using the Retinal Function Imager-A Pilot Study.Journal of clinical medicine · 2024Article
- Age-related alterations in retinal capillary function.Microvascular research · 2023Article
- Neuroprotection for Nonarteritic Central Retinal Artery Occlusion: Lessons from Acute Ischemic Stroke.Clinical ophthalmology (Auckland, N.Z.) · 2023Review
- Optical coherence tomography angiography analysis of changes in the foveal avascular zone in eyes with diabetic macular edema treated with intravitreal anti-vascular endothelial growth factor.International journal of retina and vitreous · 2022Article
- Subretinal fluid disturbs the retinal venous blood flow in central serous chorioretinopathy.Scientific reports · 2022Article
- Exploratory study of non-invasive, high-resolution functional macular imaging in subjects with diabetic retinopathy.International journal of ophthalmology · 2021Article
- Clinical applications of the retinal functional imager: A brief review.Indian journal of ophthalmology · 2019Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe Retinal Function Imager (RFI) provides in vivo and noninvasive imaging of both the retinal structure and function. REVIEW: The RFI can create capillary perfusion maps, measure blood flow velocity, and determine metabolic function including blood oximetry. It can aid clinical diagnosis as well as assess treatment response in several retinal vascular diseases including diabetic retinopathy. Blood flow velocity abnormalities have also been implicated in disease such as age-related macular degeneration and require further investigation. Compared with optical coherence tomography angiography, the RFI produces capillary maps of comparable image quality and wider field of view but it is unable to provide depth-resolved information and has longer image acquisition time. Currently, functional imaging using blood oximetry has limited applications and additional research is required.
conclusionThe RFI offers noninvasive, high-resolution imaging of retinal microvasculature by creating capillary perfusion maps. In addition, it is capable of measuring retinal blood velocity directly and performs functional imaging with retinal blood oximetry. Its clinical applications are broad and additional research with functional imaging may potentially lead to diagnosis of diseases and their progression before anatomic abnormalities become evident, but longer image acquisition times may limit its clinical adoption.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.