ArticleBMC obesity2018
Exploring the associations between systemic inflammation, obesity and healthy days: a health related quality of life (HRQOL) analysis of NHANES 2005-2008.
Article in BMC obesity, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
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- Gender predictors of adverse health.Journal of health psychology · 2026Article
- Nut Intake, Functional Limitations, and Quality of Life in Older Adults: Findings From NHANES 2003-2012.Journal of cachexia, sarcopenia and muscle · 2025Article
- Association Between Vitamin Intake and Colorectal Cancer: Evidence from NHANES Data.Journal of gastrointestinal cancer · 2024Article
- Assessing the Evidence for Causal Associations Between Body Mass Index, C-Reactive Protein, Depression, and Reported Trauma Using Mendelian Randomization.Biological psychiatry global open science · 2023Article
- Change in C-reactive protein after Roux-en-Y gastric bypass through 7 years of follow-up.Surgery for obesity and related diseases : official journal of the American Society for Bariatric Surgery · 2022Article
- Risk factors for low back pain outcome: Does it matter when they are measured?European journal of pain (London, England) · 2022Article
- Association of Body Mass Index in Midlife With Morbidity Burden in Older Adulthood and Longevity.JAMA network open · 2022Article
- Impact of selenium on the intestinal microbiome-eCBome axis in the context of diet-related metabolic health in mice.Frontiers in immunology · 2022Article
- Gender-Based Association of Coronary Artery Calcification and Framingham Risk Score With Non-alcoholic Fatty Liver Disease and Abdominal Obesity in Taiwanese Adults, a Cross-Sectional Study.Frontiers in cardiovascular medicine · 2022Article
- Host-biomaterial interactions in mesh complications after pelvic floor reconstructive surgery.Nature reviews. Urology · 2021Review
- Mental component of health-related quality of life is an independent predictor of incident functional disability among community-dwelling older people: a prospective cohort study.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2021Article
- Determinants of pain and activity limitations in foot osteoarthritis: An exploratory cross-sectional study in the Amsterdam-foot cohort.Osteoarthritis and cartilage open · 2021Article
- Relationships of inflammation trajectories with white matter volume and integrity in midlife.Brain, behavior, and immunity · 2021Article
- Understanding Covid and the associated post-infectious hyper-inflammatory state (PIMS-TS) in children.Medical hypotheses · 2020Article
- Anti-Müllerian Hormone Levels and Cardiometabolic Disturbances by Weight Status Among Men in the 1999 to 2004 National Health and Nutrition Examination Survey.Journal of the Endocrine Society · 2019Article
- Inflammation and quality of life in later life: findings from the health, well-being and aging study (SABE).Health and quality of life outcomes · 2019Article
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5 authors.
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Abstract
backgroundObesity is positively associated with low-level chronic inflammation, and negatively associated with several indices of health-related quality of life (HRQOL). It is however not clear if obesity-associated inflammation is partly responsible for the observed negative associations between obesity and HRQOL, and also whether systemic inflammation independently affects HRQOL. We conducted an exploratory analysis to investigate the relationships between obesity, systemic inflammation and indices of HRQOL, using NHANES survey data.
methodsData for the variables of interest were available for 6325 adults (aged 20-75 years, BMI > 18.5 kg/m
resultsObesity was positively associated with poor physical healthy days (OR: 1.59, 95% CI: 1.15-2.21) in unadjusted models. 'Elevated' and 'clinically raised' levels of the inflammation marker CRP were also positively associated with poor physical healthy days (OR = 1.61, 95% CI: 1.23-2.12, and OR = 2.45, 95% CI: 1.84-3.26, respectively); additionally, 'clinically raised' CRP was positively associated with mental unhealthy days (OR = 1.66, 95% CI: 1.26-2.19). The association between obesity and physical HRQOL was rendered non-significant in models including CRP. Association between 'elevated' and 'clinically raised' CRP and physical unhealthy days remained significant even after adjustment for obesity or inflammation-modulating covariates (OR = 1.36, 95% CI: 1.02-1.82, and OR = 1.75, 95% CI: 1.21-2.54, respectively).
conclusionsSystemic inflammation appears to mediate the association between obesity and physical unhealthy days. Clinically raised inflammation is an independent determinant of physical and mental unhealthy days. Importantly, elevated (but sub-clinical) inflammation is also negatively associated with physical healthy days, and may warrant more attention from a population health perspective than currently appreciated.
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