Evidence map›Paper›PMID 30123482›Full record

ArticleChemical science2018

Membrane glycomics reveal heterogeneity and quantitative distribution of cell surface sialylation.

Diane Dayoung Park, Gege Xu, Maurice Wong, Chatchai Phoomak, Mingqi Liu, Nathan E Haigh, Sopit Wongkham, Pengyuan Yang, Emanual Maverakis, Carlito B Lebrilla

Open access · diamondAbstract read
In one paragraph

Article in Chemical science, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed, 1 pooled it
3.1field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed, 1 synthesis or guideline pooled it, 59 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. Sensitive and Specific Global Cell SurfaceAnalytical chemistry · 2023
    Article
  9. Review
  10. Article
  11. Review
  12. Article
  13. Article
  14. Article
  15. Review
  16. The glycoproteomics of hawk and caiman tears.BMC veterinary research · 2021
    Article
  17. Cells · 2021
    Article
  18. Review
  19. UDP-glucose pyrophosphorylase 2, a regulator of glycogen synthesis and glycosylation, is critical for pancreatic cancer growth.Proceedings of the National Academy of Sciences of the United States of America · 2021
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 4 countries.

Diane Dayoung ParkDepartment of Chemistry , University of California , Davis , CA 95616 , USA.ORCID 0000-0003-4983-4340
Gege XuDepartment of Chemistry , University of California , Davis , CA 95616 , USA.ORCID 0000-0002-0792-2636
Maurice WongDepartment of Chemistry , University of California , Davis , CA 95616 , USA.
Chatchai PhoomakDepartment of Biochemistry , Faculty of Medicine , Khon Kaen University , Khon Kaen 40002 , Thailand.
Mingqi LiuDepartment of Chemistry , Institutes of Biomedical Sciences , Fudan University , Shanghai 200032 , China.
Nathan E HaighDepartment of Dermatology , University of California , Davis School of Medicine , Sacramento , CA 95817 , USA.
Sopit WongkhamDepartment of Biochemistry , Faculty of Medicine , Khon Kaen University , Khon Kaen 40002 , Thailand.
Pengyuan YangDepartment of Chemistry , Institutes of Biomedical Sciences , Fudan University , Shanghai 200032 , China.
Emanual MaverakisDepartment of Dermatology , University of California , Davis School of Medicine , Sacramento , CA 95817 , USA.ORCID 0000-0002-6294-6294
Carlito B LebrillaDepartment of Chemistry , University of California , Davis , CA 95616 , USA.
University of California System · USFudan University · CNKhon Kaen University · THBeth Israel Deaconess Medical Center · US

Funding

ENVIRONMENTAL TOXICOLOGYT32ES007059 · NIEHS · UNIVERSITY OF CALIFORNIA DAVIS · PI Laura S Van Winkle · 1985 to 2026
$7.9M
The incorporation of human milk oligosaccharides in brain glycoconjugatesR01GM049077 · NIGMS · UNIVERSITY OF CALIFORNIA DAVIS · PI LEBRILLA, CARLITO B · 1999 to 2024
$6.3M
Investigation and Development of New Therapeutic Avenues for SclerodermaDP2OD008752 · OD · UNIVERSITY OF CALIFORNIA AT DAVIS · PI MAVERAKIS, EMANUAL M. · 2011 to 2016
$2.8M
NIEHS NIH HHS T32 ES007059NIGMS NIH HHS R01 GM049077NIH HHS DP2 OD008752
6 · The paper itself

Abstract

Given that unnatural sugar expression is metabolically achieved, the kinetics and disposition of incorporation can lend insight into the temporal and localization preferences of sialylation across the cell surface. However, common detection schemes lack the ability to detail the molecular diversity and distribution of target moieties. Here we employed a mass spectrometric approach to trace the placement of azido sialic acids on membrane glycoconjugates, which revealed substantial variations in incorporation efficiencies between

Identifiers

PMID30123482
PMCPMC6063140
OpenAlexW2810571492

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.