ReviewPain research & management2018
Emotional and Motivational Pain Processing: Current State of Knowledge and Perspectives in Translational Research.
Review in Pain research & management, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
37 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Virtual reality distraction for acute pain in children.The Cochrane database of systematic reviews · 2020Pooled it
- Temporal Interference Stimulation of the Motor Cortex Produces Frequency-Dependent Analgesia.bioRxiv : the preprint server for biology · 2026Article
- Neuropeptides in the Management of Alzheimer's Disease: From Pathophysiology to Therapeutic Opportunities.International journal of molecular sciences · 2026Review
- Factors Associated With Craniocervical and Otological Symptoms in Healthcare Workers During Covid-19 Pandemic: A Cross-Sectional Study.Journal of oral rehabilitation · 2026Article
- Timing of depressive episode onset relative to chronic pain reveals distinct patterns of affective and multisite pain.Frontiers in psychiatry · 2026Article
- Delta-9-tetrahydrocannabinol and Cannabidiol for Pain: Preclinical and Clinical Models.Current topics in behavioral neurosciences · 2026Review
- Perspectives on Pain: A Narrative Review of Pain Beliefs, Coping, and Clinical Implications.Journal of pain research · 2026Review
- Article
- Behavioral Characteristics of Female Rats on the Model of Pain Syndrome in the Maxillofacial Region.Bulletin of experimental biology and medicine · 2025Article
- Physiological framework for non-invasive detection and objective nociception activity in communicative patients: a pilot case study.Frontiers in physiology · 2025Article
- Investigating the impact of perceived stress and anxiety on nonspecific low back pain among future health care professionals in Hungary: a cross-sectional study.Frontiers in psychology · 2025Article
- A multisite validation of brain white matter pathways of resilience to chronic back pain.eLife · 2024Article
- Brain white matter pathways of resilience to chronic back pain: a multisite validation.bioRxiv : the preprint server for biology · 2024Article
- A comprehensive review on ziconotide.Heliyon · 2024Review
- Pain mechanisms in the transgender individual: a review.Frontiers in pain research (Lausanne, Switzerland) · 2024Review
- Personality systems interactions theory: an integrative framework complementing the study of the motivational and volitional dynamics underlying adjustment to chronic pain.Frontiers in pain research (Lausanne, Switzerland) · 2024Article
- Pain-Related Cognitive Processes, Pain Interference, and Alexithymia in Patients With Primary Headaches.Cureus · 2023Article
- Differences in the neural basis and transcriptomic patterns in acute and persistent pain-related anxiety-like behaviors.Frontiers in molecular neuroscience · 2023Article
- Higher adverse childhood experiences interference with targeted early intervention to reduce persistence of adult subacute pain: a feasibility open trial.Frontiers in psychology · 2023Article
- Animal Venom Peptides Cause Antinociceptive Effects by Voltage-gated Calcium Channels Activity Blockage.Current neuropharmacology · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Pain elicits fear and anxiety and promotes escape, avoidance, and adaptive behaviors that are essential for survival. When pain persists, motivational priority and attention shift to pain-related information. Such a shift often results in impaired functionality, leading to maladaptive pain-related fear and anxiety and escape and avoidance behaviors. Neuroimaging studies in chronic pain patients have established that brain activity, especially in cortical and mesolimbic regions, is different from activity observed during acute pain in control subjects. In this review, we discuss the psychophysiological and neuronal factors that may be associated with the transition to chronic pain. We review information from human studies on neural circuits involved in emotional and motivational pain processing and how these circuits are altered in chronic pain conditions. We then highlight findings from animal research that can increase our understanding of the molecular and cellular mechanisms underlying emotional-motivational pain processing in the brain. Finally, we discuss how translational approaches incorporating results from both human and animal investigations may aid in accelerating the discovery of therapies.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.