Evidence map›Paper›PMID 30123369›Full record

ArticleCellular and molecular bioengineering2018

Cardiovascular function and structure are preserved despite induced ablation of BMP1-related proteinases.

Mark J Golob, Dawiyat Massoudi, Diana M Tabima, James L Johnston, Gregory D Wolf, Timothy A Hacker, Daniel S Greenspan, Naomi C Chesler

Abstract read
In one paragraph

Article in Cellular and molecular bioengineering, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. IGF-II regulates lysyl oxidase propeptide and mediates its effects in part via basic helix-loop-helix E40.Matrix biology : journal of the International Society for Matrix Biology · 2024
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Mark J GolobDepartment of Biomedical Engineering, University of Wisconsin-Madison College of Engineering, Madison, WI 53706 USA.
Dawiyat MassoudiDepartment of Cell and Regenerative Biology, University of Wisconsin-Madison School of Medicine and Public Health, Madison, WI 53706 USA.
Diana M TabimaDepartment of Biomedical Engineering, University of Wisconsin-Madison College of Engineering, Madison, WI 53706 USA.
James L JohnstonDepartment of Biomedical Engineering, University of Wisconsin-Madison College of Engineering, Madison, WI 53706 USA.
Gregory D WolfDepartment of Biomedical Engineering, University of Wisconsin-Madison College of Engineering, Madison, WI 53706 USA.
Timothy A HackerDepartment of Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI 53706 USA.
Daniel S GreenspanDepartment of Cell and Regenerative Biology, University of Wisconsin-Madison School of Medicine and Public Health, Madison, WI 53706 USA.
Naomi C CheslerDepartment of Biomedical Engineering, University of Wisconsin-Madison College of Engineering, Madison, WI 53706 USA.
Madison Area Technical College · USUniversity of Wisconsin–Madison · US

Funding

Vascular collagen accumulation & mechanical mechanisms in pulmonary hypertensionR01HL086939 · NHLBI · UNIVERSITY OF WISCONSIN-MADISON · PI CHESLER, NAOMI C · 2007 to 2016
$3.6M
Molecular Biology Of Collagen Type VR01AR047746 · NIAMS · UNIVERSITY OF WISCONSIN-MADISON · PI GREENSPAN, DANIEL S · 2001 to 2013
$3.0M
Biology and Pathologies of Type V CollagenR56AR047746 · NIAMS · UNIVERSITY OF WISCONSIN-MADISON · PI GREENSPAN, DANIEL S · 2008 to 2008
$291k
NHLBI NIH HHS R01 HL086939NIAMS NIH HHS R01 AR047746NIAMS NIH HHS R56 AR047746
6 · The paper itself

Abstract

introductionBone morphogenetic protein 1 (BMP1) is part of an extracellular metalloproteinase family that biosynthetically processes procollagen molecules. BMP1- and tolloid-like (TLL1) proteinases mediate the cleavage of carboxyl peptides from procollagen molecules, which is a crucial step in fibrillar collagen synthesis. Ablating the genes that encode BMP1-related proteinases (

methodsVentricular and vascular structure and function were comprehensively quantified in BT

results

conclusionsMaintained ventricular and vascular structure and function despite post-natal ablation of

Indexed as

arterial stiffnesscollagenelastic modulusmammalian tolloidpressure-volume loop

Identifiers

PMID30123369
PMCPMC6094387
OpenAlexW2807173124

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.