Evidence map›Paper›PMID 30123312›Full record

ArticleJournal of occupational medicine and toxicology (London, England)2018

Impact of shift work on the diurnal cortisol rhythm: a one-year longitudinal study in junior physicians.

Jian Li, Martin Bidlingmaier, Raluca Petru, Francisco Pedrosa Gil, Adrian Loerbroks, Peter Angerer

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of occupational medicine and toxicology (London, England), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed, 1 pooled it
2.7field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 1 synthesis or guideline pooled it, 49 citations in OpenAlex.

  1. Pooled it
  2. Canine-Assisted Therapy Improves Well-Being in Nurses.International journal of environmental research and public health · 2019
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 1 country.

Jian Li1Institute of Occupational, Social and Environmental Medicine, Centre for Health and Society, Faculty of Medicine, University of Düsseldorf, Universitätsstraße 1, 40225 Düsseldorf, Germany.ORCID 0000-0003-2614-4291
Martin Bidlingmaier2Endocrine Research Unit, Medizinische Klinik und Poliklinik IV, Ludwig-Maximilians-University, Munich, Germany.
Raluca Petru3Institute and Outpatient Clinic for Occupational, Social and Environmental Medicine, WHO Collaborating Centre for Occupational Health, Ludwig-Maximilians-University, Munich, Germany.
Francisco Pedrosa GilClinic for Psychiatry, Psychotherapy and Psychosomatics, Helios Vogtland Clinical Center, Plauen, Germany.
Adrian Loerbroks1Institute of Occupational, Social and Environmental Medicine, Centre for Health and Society, Faculty of Medicine, University of Düsseldorf, Universitätsstraße 1, 40225 Düsseldorf, Germany.
Peter Angerer1Institute of Occupational, Social and Environmental Medicine, Centre for Health and Society, Faculty of Medicine, University of Düsseldorf, Universitätsstraße 1, 40225 Düsseldorf, Germany.
Heinrich Heine University Düsseldorf · DEHelios Vogtland Klinikum Plauen · DEKlinik und Poliklinik für Orthopädie, Physikalische Medizin und Rehabilitation · DELudwig-Maximilians-Universität München · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundCumulative epidemiological evidence suggests that shift work exerts harmful effects on human health. However, the physiological mechanisms are not well understood. This study aimed to examine the impact of shift work on the dysregulation of the hypothalamic-pituitary-adrenal axis, i.e. diurnal cortisol rhythm.

methodsSeventy physicians with a mean age 30 years participated in this one-year longitudinal study. Working schedules, either shift work or regular schedules with day shift, were assessed at baseline. Salivary cortisol samples were collected on two consecutive regular working days, four times a day (including waking, + 4 h, + 8 h, and + 16 h), at both baseline and the one-year follow-up. The diurnal cortisol decline (slope) and total cortisol concentration (area under the curve, AUC) were calculated.

resultsAfter adjusting for cortisol secretion at baseline and numerous covariates, shift work at baseline significantly predicted a steeper slope (

conclusionsOur findings support the notion that shift work changes the diurnal cortisol pattern, and is predictive of increased cortisol secretion consequently in junior physicians.

Indexed as

CortisolHypothalamic-pituitary-adrenal axisLongitudinal studyOccupational healthShift work

Identifiers

PMID30123312
PMCPMC6090626
OpenAlexW2884029927

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.