Evidence map›Paper›PMID 30123243›Full record

Trial reportNeural plasticity2018

Beneficial Effect of Multidomain Cognitive Training on the Neuropsychological Performance of Patients with Early-Stage Alzheimer's Disease.

Anastasia Nousia, Vasileios Siokas, Eleni Aretouli, Lambros Messinis, Athina-Maria Aloizou, Maria Martzoukou, Maria Karala, Charalampos Koumpoulis, Grigorios Nasios, Efthimios Dardiotis

Open access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Neural plasticity, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed, 6 pooled it
3.7field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 6 syntheses or guidelines pooled it, 64 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Anastasia NousiaDepartment of Speech and Language Therapy, Higher Educational Institute of Epirus, Ioannina, Greece.ORCID 0000-0003-1303-0690
Vasileios SiokasDepartment of Neurology, University Hospital of Larissa, University of Thessaly, Larissa, Greece.
Eleni AretouliLab of Cognitive Neuroscience, School of Psychology, Aristotle University of Thessaloniki, Thessaloniki, Greece.
Lambros MessinisNeuropsychology Section, Department of Neurology, University of Patras Medical School, Patras, Greece.ORCID 0000-0002-3216-9025
Athina-Maria AloizouDepartment of Neurology, University Hospital of Larissa, University of Thessaly, Larissa, Greece.
Maria MartzoukouDepartment of Speech and Language Therapy, Higher Educational Institute of Epirus, Ioannina, Greece.
Maria KaralaDepartment of Speech and Language Therapy, Higher Educational Institute of Epirus, Ioannina, Greece.
Charalampos KoumpoulisOlympion Rehabilitation Hospital, Ioannina, Greece.
Grigorios NasiosDepartment of Speech and Language Therapy, Higher Educational Institute of Epirus, Ioannina, Greece.ORCID 0000-0001-7495-6863
Efthimios DardiotisDepartment of Neurology, University Hospital of Larissa, University of Thessaly, Larissa, Greece.
University of Thessaly · GRAristotle University of Thessaloniki · GRUniversity Hospital of Ioannina · GRUniversity of Patras · GR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background and Purpose: There is an increasing interest in the effect of nonpharmacological interventions on the course of patients with Alzheimer's disease (AD). The objective of the present study is to determine the benefits of a structured, multidomain, mostly computer-based, cognitive training (MCT) οn the cognitive performance of patients with early-stage AD. Method: Fifty patients with early-stage AD participated in the study. Patients were randomly allocated either to the training program group ( Results: Analysis showed that in controls, delayed memory and executive function had deteriorated over the observation period of 15 weeks, while the training group improved their performance in word recognition, Boston Naming Test (BNT), semantic fluency (SF), clock-drawing test (CDT), digit span forward (DSF), digit span backward (DSB), trail-making test A (TMT A), and trail-making test B (TMT B). Comparison between the training group and the controls showed that MCT had a significant beneficial effect in delayed memory, naming, semantic fluency, visuospatial ability, executive functions, attention, and processing speed. Conclusions: The study provides evidence of a beneficial effect of MCT with an emphasis on cognitive-language performance of patients with early-stage AD. Considering the limited efficacy of current pharmacological therapies in AD, concurrent computer-based MCT may represent an additional enhancing treatment option in early-stage AD patients.

Indexed as

Neuropsychological TestsAgedAged, 80 and overAlzheimer DiseaseCognitive Behavioral TherapyEarly DiagnosisExecutive FunctionFemaleFollow-Up StudiesHumansMalePsychomotor PerformanceTherapy, Computer-AssistedTreatment Outcome

Identifiers

PMID30123243
PMCPMC6079404
OpenAlexW2860007030

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.