Evidence map›Paper›PMID 30123215›Full record

ArticleFrontiers in immunology2018

Intestinal Epithelial Cells Regulate Gut Eotaxin Responses and Severity of Allergy.

Eunsoo Kim, Melanie Lembert, Ghaith M Fallata, John C Rowe, Tara L Martin, Abhay R Satoskar, Nicholas V Reo, Oleg Paliy, Estelle Cormet-Boyaka, Prosper N Boyaka

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.6field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 17 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Article
  5. Inhibition of elastase enhances the adjuvanticity of alum and promotes anti-SARS-CoV-2 systemic and mucosal immunity.Proceedings of the National Academy of Sciences of the United States of America · 2021
    Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. Article
  11. Biomarkers in Food Allergy.Current allergy and asthma reports · 2018
    Review
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Eunsoo KimDepartment of Veterinary Biosciences, The Ohio State University, Columbus, OH, United States.
Melanie LembertDepartment of Veterinary Biosciences, The Ohio State University, Columbus, OH, United States.
Ghaith M FallataDepartment of Biochemistry and Molecular Biology, Boonshoft School of Medicine, Wright State University, Dayton, OH, United States.
John C RoweDepartment of Veterinary Biosciences, The Ohio State University, Columbus, OH, United States.
Tara L MartinDepartment of Veterinary Biosciences, The Ohio State University, Columbus, OH, United States.
Abhay R SatoskarDepartment of Pathology, The Ohio State University, Columbus, OH, United States.
Nicholas V ReoDepartment of Biochemistry and Molecular Biology, Boonshoft School of Medicine, Wright State University, Dayton, OH, United States.
Oleg PaliyDepartment of Biochemistry and Molecular Biology, Boonshoft School of Medicine, Wright State University, Dayton, OH, United States.
Estelle Cormet-BoyakaDepartment of Veterinary Biosciences, The Ohio State University, Columbus, OH, United States.
Prosper N BoyakaDepartment of Veterinary Biosciences, The Ohio State University, Columbus, OH, United States.
The Ohio State University · USWright State University · US

Funding

A novel lactic acid bacteria-based norovirus vaccineR01AI123661 · NIAID · OHIO STATE UNIVERSITY · PI BOYAKA, PROSPER N, HE, XIAOMING · 2016 to 2020
$3.0M
Regulation of mucosal IgA and allergic inflammation by intestinal epithelial cellsR01DK101323 · NIDDK · OHIO STATE UNIVERSITY · PI BOYAKA, PROSPER N · 2015 to 2019
$1.7M
Short Trem Research Training for Veterinary StudentsT35OD010977 · OD · OHIO STATE UNIVERSITY · PI Christine A Petersen · 2012 to 2026
$1.1M
NIAID NIH HHS R01 AI123661NIDDK NIH HHS R01 DK101323NIH HHS T35 OD010977
6 · The paper itself

Abstract

Intestinal epithelial cells (IECs) are known to regulate allergic sensitization. We addressed the role of the intrinsic IKKβ signaling in IECs in the effector phase of allergy following oral allergen challenge and its impact on the severity of responses is poorly. Upon orally sensitization by co-administration of ovalbumin with cholera toxin as adjuvant, wild-type and mice lacking IKKβ in IECs (IKKβ

Indexed as

Administration, OralAllergensAnimalsChemokine CCL11Disease Models, AnimalEosinophilsHypersensitivityImmunoglobulin EIntestinal MucosaMiceMice, KnockoutNF-kappa BOvalbuminSeverity of Illness IndexAllergensChemokine CCL11Immunoglobulin ENF-kappa BOvalbuminallergyeosinophilseotaxinsintestinal epithelial cellsNF-κB

Identifiers

PMID30123215
PMCPMC6085436
OpenAlexW2887541636

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.