Evidence map›Paper›PMID 30123191›Full record

ArticleFrontiers in microbiology2018

Novel Glycopolymer Eradicates Antibiotic- and CCCP-Induced Persister Cells in

Vidya P Narayanaswamy, Laura L Keagy, Kathryn Duris, William Wiesmann, Allister J Loughran, Stacy M Townsend, Shenda Baker

Registry-linked trialOpen access · goldAbstract read
In one paragraph

Article in Frontiers in microbiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04601532 (Randomized Controlled Trial Assessing a Novel Glycopolymer Compound in the Treatment of Superficial Partial-thickness Burns), which is not on this map. Cited by 28 papers.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
3.1field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04601532 phase4terminatednot on this mapstarted 2021, after this paper: background citation

Randomized Controlled Trial Assessing a Novel Glycopolymer Compound in the Treatment of Superficial Partial-thickness Burns

TypeinterventionalSponsorJ. Peter Rubin, MDRan2021 to 2022Enrolled26ConditionsSuperficial Partial Thickness BurnArmsCatasyn™ Advanced Technology Hydrogel and SynePure™ Wound Cleanser, Silver Sulfadiazine
3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 60 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Multivalent Glycopolymer Design Unlocks Antimicrobial Activity of 2-Deoxyglucose.Angewandte Chemie (International ed. in English) · 2026
    Article
  5. Article
  6. Article
  7. A rational approach to discovering new persister control agents.Antimicrobial agents and chemotherapy · 2025
    Article
  8. Article
  9. Eradication ofACS infectious diseases · 2024
    Article
  10. Ultrasound-Mediated Antibiotic Delivery to In Vivo Biofilm Infections: A Review.Chembiochem : a European journal of chemical biology · 2024
    Review
  11. Article
  12. Genome Analysis ofPathogens (Basel, Switzerland) · 2023
    Article
  13. Article
  14. Article
  15. Review
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Vidya P NarayanaswamySynedgen, Inc., Claremont, CA, United States.
Laura L KeagySynedgen, Inc., Claremont, CA, United States.
Kathryn DurisSynedgen, Inc., Claremont, CA, United States.
William WiesmannSynedgen, Inc., Claremont, CA, United States.
Allister J LoughranSynedgen, Inc., Claremont, CA, United States.
Stacy M TownsendSynedgen, Inc., Claremont, CA, United States.
Shenda BakerSynedgen, Inc., Claremont, CA, United States.
Synedgen (United States) · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Antibiotic treatments often fail to completely eradicate a bacterial infection, leaving behind an antibiotic-tolerant subpopulation of intact bacterial cells called persisters. Persisters are considered a major cause for treatment failure and are thought to greatly contribute to the recalcitrance of chronic infections.

Indexed as

chronic infectionglycopolymerPAAGpersister cellsPseudomonas aeruginosa

Identifiers

PMID30123191
PMCPMC6085434
OpenAlexW2884762837

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.