Evidence map›Paper›PMID 30123178›Full record

ReviewFrontiers in neurology2018

Impact of Tremor on Patients With Early Stage Parkinson's Disease.

Lauren E Heusinkveld, Mallory L Hacker, Maxim Turchan, Thomas L Davis, David Charles

Registry-linked trialOpen access · goldAbstract readReview
In one paragraph

Review in Frontiers in neurology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05268887 (Acute Treatment of Parkinson's Disease With Gamma Frequency Stimulation), which is not on this map. Cited by 31 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed, 1 pooled it
2.2field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05268887 narecruitingnot on this mapstarted 2022, after this paper: background citation

Acute Treatment of Parkinson's Disease With Gamma Frequency Stimulation

TypeinterventionalSponsorMassachusetts Institute of TechnologyRan2022 to 2027Enrolled40ConditionsParkinson DiseaseArmsGENUS device (Active Settings), GENUS device (Sham settings)
3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 1 synthesis or guideline pooled it, 64 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Reliability of Neuroimaging and Neurophysiological Tremor Features in Parkinson's Disease.Movement disorders : official journal of the Movement Disorder Society · 2025
    Article
  9. Burden of tremor in Parkinson's disease: A survey study.Journal of Parkinson's disease · 2025
    Article
  10. Review
  11. An Adaptable Phase-Tracking System for Parkinsonian Rest Tremor: Design and In-Clinic Feasibility.IEEE journal of translational engineering in health and medicine · 2025
    Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. The Clinical Profile of Tremor in Parkinson's Disease.Movement disorders clinical practice · 2023
    Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Lauren E HeusinkveldLaboratory of Molecular Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, United States.
Mallory L HackerDepartment of Neurology, Vanderbilt University Medical Center, Nashville, TN, United States.
Maxim TurchanDepartment of Neurology, Vanderbilt University Medical Center, Nashville, TN, United States.
Thomas L DavisDepartment of Neurology, Vanderbilt University Medical Center, Nashville, TN, United States.
David CharlesDepartment of Neurology, Vanderbilt University Medical Center, Nashville, TN, United States.
Vanderbilt University Medical Center · USNational Institutes of Health · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Tremor is one of the most visible features of Parkinson's disease (PD), and the majority of PD patients experience tremor during the course of the disease. However, the distress caused by this cardinal motor feature for patients early in the course of their PD is commonly underappreciated. People living with early stage PD often experience intense embarrassment and difficulties due to their tremor that limit social interactions, and tremor frequently interferes with the ability to perform activities of daily living and simple tasks at home and work. Although tremor is primarily managed with medications, both tremor response and satisfaction with medical therapy are highly variable. This review offers an overview of reports of the patient experience of tremor in early stage PD and current management options for this cardinal motor feature.

Indexed as

deep brain stimulationParkinson's diseasepatient perspectivestremortremor management

Identifiers

PMID30123178
PMCPMC6085452
OpenAlexW2884924428

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.