Evidence map›Paper›PMID 30123094›Full record

ArticleCancer cell international2018

Circ-ZEB1.33 promotes the proliferation of human HCC by sponging miR-200a-3p and upregulating CDK6.

Yuhua Gong, Jinzhong Mao, Di Wu, Xuemei Wang, Long Li, Liang Zhu, Rong Song

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancer cell international, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 84 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
84citing papers in PubMed, 2 pooled it
6.7field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

84 citing papers in PubMed, 2 syntheses or guidelines pooled it, 111 citations in OpenAlex.

  1. Pooled it
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  3. Review
  4. Review
  5. Article
  6. Review
  7. Circular RNAs and Cancers.Advances in experimental medicine and biology · 2025
    Review
  8. Article
  9. Article
  10. Article
  11. Emerging Role of Circular RNAs in Hepatocellular Carcinoma Immunotherapy.International journal of molecular sciences · 2023
    Review
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  14. Article
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  18. Article
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24 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Yuhua GongDepartment of Clinical Laboratory, The Third People's Hospital of Zhenjiang, 300 Daijiamen, Zhenjiang, 212005 Jiangsu China.
Jinzhong MaoDepartment of Radiology, The Third People's Hospital of Zhenjiang, 300 Daijiamen, Zhenjiang, 212005 Jiangsu China.
Di WuDepartment of Hepatosis Inpatient, The Third People's Hospital of Zhenjiang, 300 Daijiamen, Zhenjiang, 212005 Jiangsu China.
Xuemei WangDepartment of Clinical Laboratory, The Third People's Hospital of Zhenjiang, 300 Daijiamen, Zhenjiang, 212005 Jiangsu China.
Long LiDepartment of Clinical Laboratory, The Third People's Hospital of Zhenjiang, 300 Daijiamen, Zhenjiang, 212005 Jiangsu China.
Liang ZhuDepartment of Clinical Laboratory, The Third People's Hospital of Zhenjiang, 300 Daijiamen, Zhenjiang, 212005 Jiangsu China.
Rong SongDepartment of Clinical Laboratory, The Third People's Hospital of Zhenjiang, 300 Daijiamen, Zhenjiang, 212005 Jiangsu China.
Jiangsu University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAccumulating data indicated that circRNA plays important roles in regulating many biological processes of the tumor, the present study is designated for exploring roles of the circ-ZEB1.33-miR-200a-3p-CDK6 regulating axis in human hepatocellular carcinoma (HCC).

methodsThe regulation axis as predicted by using online tool circNet, the expression and correlation of circ-ZEB1.33-miR-200a-3p-CDK6 was verified in human HCC. The diagnostic value of both tumor and serum circ-ZEB1.33 was estimated by using clinical samples. The roles of circ-ZEB1.33-miR-200a-3p-CDK6 in regulating cell cycle were explored by using in vitro studies.

resultsOverexpression of circ-ZEB1.33 and CDK6, downregulation of miR-200a-3p were detected in human HCC tissues, negative correlation between circ-ZEB1.33 and miR-200a-3p, positive correlation between circ-ZEB1.33 and CDK6 were confirmed in human HCC tissues. Tissue and serum circ-ZEB1.33 were related to different TMN stages and prognosis in HCC patients. RNA pull-down assay implied that circ-ZEB1.33 could decrease miR-200a-3p by sponging miR-200a-3p, and the luciferase reporter assay indicated that miR-200a-3p could downregulate CDK6 transcription by targeting its 3'UTR. The in vitro assays indicated that circ-ZEB1.33 could promote the proliferation of HCC cells by increasing the percentage of S phase regulated by CDK6/Rb.

conclusionProliferation promotion roles of the circ-ZEB1.33-miR-200a-3p-CDK6 regulating axis are existed and verified in human HCC, both tumor and serum circ-ZEB1.33 can serve as an indicator for the prognosis of HCC patients.

Indexed as

CDK6Circ-ZEB1.33HCCmiR-200a-3p

Identifiers

PMID30123094
PMCPMC6090603
OpenAlexW2885746990

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.