ArticleOncoTargets and therapy2018
Phytochemical analysis and antioxidant and anticancer activities of mastic gum resin from
Article in OncoTargets and therapy, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 41 citations in OpenAlex.
- Pistacia atlantica sub. Kurdica can improve insulin resistance in patients with non-alcoholic fatty liver disease: a randomized clinical trial.BMC complementary medicine and therapies · 2026Trial
- Pistacia atlantica can improve oxidative status in patients with metabolic dysfunction-associated fatty liver disease.Scientific reports · 2025Trial
- Alpha-pinene modulates hippocampal MAPKs/c-Fos pathways during morphine dependence and withdrawal in rats.Psychopharmacology · 2026Article
- Exploring chemical composition, anti-acetylcholinesterase, and anticancer activities ofPharmaceutical biology · 2025Article
- Molecular identification and antimicrobial evaluation of Pistacia atlantica essential oil against multidrug-resistant Acinetobacter baumannii.Molecular biology reports · 2025Article
- Functional Beverages From Frankincense andFood science & nutrition · 2025Article
- Extraction Methods Shape the Phenolic Composition and Bioactivities of Defatted MoroccanAntioxidants (Basel, Switzerland) · 2025Article
- A Traditional Gum Exudate FromFood science & nutrition · 2025Article
- In Vitro Antitumor and Antimetastatic Activity of a New Lapachol Derivative against Metastatic Breast Carcinoma.Asian Pacific journal of cancer prevention : APJCP · 2024Article
- Multiplicative Effects of Essential Oils and Other Active Components on Skin Tissue and Skin Cancers.International journal of molecular sciences · 2024Review
- Evaluation of the cytotoxic activities of the essential oil from Pistacia atlantica Desf. oleoresin on human gastric cancer cell lines.Medical oncology (Northwood, London, England) · 2024Article
- Nutraceutical Content and Biological Properties of Lipophilic and Hydrophilic Fractions of the Phytocomplex fromPlants (Basel, Switzerland) · 2024Article
- Preparation and characterization ofFrontiers in pharmacology · 2024Article
- Why Should Pistachio Be a Regular Food in Our Diet?Nutrients · 2022Review
- Natural Products for Pancreatic Cancer Treatment: From Traditional Medicine to Modern Drug Discovery.Nutrients · 2021Review
- Phytochemical Characterization and Effects on Cell Proliferation of Lentisk (Pistacia lentiscus) Berry Oil: a Revalued Source of Phenolics.Plant foods for human nutrition (Dordrecht, Netherlands) · 2020Article
- The Short-Term Effects ofGalen medical journal · 2020Article
- Kampo Therapies and the Use of Herbal Medicines in the Dentistry in Japan.Medicines (Basel, Switzerland) · 2019Review
Corrections and comments
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Authors and funding
1 author at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe mastic gum resin has been used in traditional Kurdish medicine for treating various disorders such as topical wound and gastric ulcer. The study designed to evaluate the total polyphenol and flavonoid content, free radical scavenging activity, and anticancer effects of mastic gum resin derived from MATERIALS AND
methodsFolin -Ciocalteau and the aluminum chloride colorimetric assays were used to determine the total phenol and flavonoid contents in the mastic gum resin respectively. Whereas, DPPH and ABTS+ assays were used to determine the antioxidant activities of mastic gum resin. Regarding anticancer activities, the MTT assay was used to study the effect of mastic gum resin on the proliferation of various cancer cells and the morphological changes were identified after Acridine Orange/Propidium Iodide staining. Flow cytometry was applied to determine the influence of mastic gum resin on the apoptosis rate by Annexin V double staining and to investigate the influence on cell cycle progression. Caspase colorimetric assay was used to estimate the hallmark enzyme of apoptosis, and finally RNA were obtained from COLO205 cells and analyzed by qRT-PCR analyses.
resultsThe MTT results showed that the mastic gum resin at concentrations from 0.01 to 100 μM induced death of cancer cells in a dose and time-dependent manner. The mastic gum resin suppressed proliferation of human cancer cells with 72 h IC
conclusionIt was confirmed that the antiproliferative efficacy of the resin is positively correlated with its polyphenolic contents, suggesting a causal link related to exudate content of phenolic acid and flavonoids. The results revealed that the mastic gum resin has potential to be developed as an anticancer and antioxidant product due to its high content of polyphenol compounds.
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