ArticleNeuropsychiatric disease and treatment2018
Resting-state functional changes in the precuneus within first-episode drug-naive patients with MDD.
Article in Neuropsychiatric disease and treatment, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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22 citing papers in PubMed, 48 citations in OpenAlex.
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- Alteration of whole-brain amplitude of low-frequency fluctuation and degree centrality in patients with mild to moderate depression: A resting-state functional magnetic resonance imaging study.Frontiers in psychiatry · 2022Article
- Body-mind relaxation meditation modulates the thalamocortical functional connectivity in major depressive disorder: a preliminary resting-state fMRI study.Translational psychiatry · 2021Article
- Individualized diagnosis of major depressive disorder via multivariate pattern analysis of thalamic sMRI features.BMC psychiatry · 2021Article
- Altered spontaneous neural activity in the precuneus, middle and superior frontal gyri, and hippocampus in college students with subclinical depression.BMC psychiatry · 2021Article
- Elevated peripheral inflammation is associated with attenuated striatal reward anticipation in major depressive disorder.Brain, behavior, and immunity · 2021Article
- Functional plasticity abnormalities over the lifespan of first-episode patients with major depressive disorder: a resting state fMRI study.Annals of translational medicine · 2021Article
- Aberrant Topological Patterns of Structural Covariance Networks in Cognitively Normal Elderly Adults With Mild Behavioral Impairment.Frontiers in neuroanatomy · 2021Article
- The Function and Structure of Precuneus Is Associated With Subjective Sleep Quality in Major Depression.Frontiers in psychiatry · 2021Article
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Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMajor depressive disorder (MDD) is a leading psychiatric disorder that has a lack of biomarkers for a diagnosis. PURPOSE: The objective of this study was to examine the structural and functional change in the precuneus within first-episode drug naive patients with MDD.
methodsThirty-two first episode drug-naive patients with MDD and thirty healthy controls (HCs) were recruited in this study; the structural MRI and fMRI data were collected using the 3.0 T Trio Siemens System. All the patients were interviewed using the HAMD-17.
resultsThe difference between gray matter volume within the two groups was not observed. Results indicated that the low-frequency fluctuations (ALFF), fractional ALFF (fALFF) and regional homogeneity values of the precuneus within first-episode drug-naive patients with MDD were lower than the HCs. In addition, the fALFF value of the MDD was negatively and statistically significantly correlated with the HAMD-17 total score (
conclusionThe current study found abnormal activity of the precuneus at resting state in first-episode drug-naive patients with MDD, indicating that activity within the precuneus may be a potential biomarker for the diagnosis of MDD.
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