ArticleNeuropsychiatric disease and treatment2018
Tinnitus distress is associated with enhanced resting-state functional connectivity within the default mode network.
Article in Neuropsychiatric disease and treatment, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed.
- Therapy effect of cochleural alternating acoustic beam therapy versus traditional sound therapy for managing chronic idiopathic tinnitus patients.Scientific reports · 2024Trial
- Tinnitus.Nature reviews. Disease primers · 2026Review
- A large-scale, multi-site examination of resting state functional connectivity in tinnitus.Scientific reports · 2025Article
- Improvement of Chronic Tinnitus Following Personalized, Parcel-guided Accelerated rTMS: Feasibility in a Retrospective Case Series.Brain topography · 2025Article
- Review
- Frailty links the heterogeneity of tinnitus disorder and response to interventions in older patients.Frontiers in neurology · 2025Review
- Topological features of brain functional networks are reorganized during chronic tinnitus: A graph-theoretical study.The European journal of neuroscience · 2025Article
- Tumor characteristics, brain functional activity, and connectivity of tinnitus in patients with vestibular schwannoma: a pilot study.Quantitative imaging in medicine and surgery · 2024Article
- Comparative study on structural and functional brain differences in mild cognitive impairment patients with tinnitus.Frontiers in aging neuroscience · 2024Article
- [Progress in neural network mechanism of tinnitus using functional magnetic resonance imaging].Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology head and neck surgery · 2023Article
- Disruptions of default mode network and precuneus connectivity associated with cognitive dysfunctions in tinnitus.Scientific reports · 2023Article
- An examination of the reliability of seed-to-seed resting state functional connectivity in tinnitus patients.Neuroimage. Reports · 2023Article
- Differential cortical activation patterns: pioneering sub-classification of tinnitus with and without hyperacusis by combining audiometry, gamma oscillations, and hemodynamics.Frontiers in neuroscience · 2023Article
- Resting-state Networks in Tinnitus : A Scoping Review.Clinical neuroradiology · 2022Article
- Tinnitus and the Triple Network Model: A Perspective.Clinical and experimental otorhinolaryngology · 2022Review
- Aberrant functional and effective connectivity of the frontostriatal network in unilateral acute tinnitus patients with hearing loss.Brain imaging and behavior · 2022Article
- Altered brain network topology in children with auditory processing disorder: A resting-state multi-echo fMRI study.NeuroImage. Clinical · 2022Article
- A large-scale diffusion imaging study of tinnitus and hearing loss.Scientific reports · 2021Article
- Visual snow syndrome, the spectrum of perceptual disorders, and migraine as a common risk factor: A narrative review.Headache · 2021Review
- Multidisciplinary Tinnitus Research: Challenges and Future Directions From the Perspective of Early Stage Researchers.Frontiers in aging neuroscience · 2021Review
Corrections and comments
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Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThe default mode network (DMN) has been confirmed to be involved in chronic tinnitus perception. Tinnitus distress may be associated with abnormal functional connectivity (FC) within the DMN regions. The goal of this study was to determine whether tinnitus disrupted the FC patterns within the DMN as measured by using resting-state functional magnetic resonance imaging approach. PATIENTS AND
methodsResting-state functional magnetic resonance imaging scans were acquired from 40 chronic bilateral tinnitus patients and 41 healthy controls. Both were age, sex, and education well-matched with normal hearing. Two important DMN regions, the anterior cingulate cortex and posterior cingulate cortex, were chosen as seed regions to detect the FC patterns within the DMN and then determine whether these changes were linked to clinical measures of tinnitus such as tinnitus duration and tinnitus severity.
resultsCompared with healthy controls, chronic tinnitus patients manifested significantly enhanced FC between the anterior cingulate cortex and left precuneus, which was correlated with the tinnitus duration (
conclusionChronic tinnitus patients showed disrupted FC patterns within the DMN regions which are correlated with tinnitus distress. Increased resting-state connectivity pattern of the DMN may play a pivotal role in neuropathological features underlying chronic tinnitus.
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