Evidence map›Paper›PMID 30122554›Full record

ArticleCell metabolism2018

Perturbed Redox Signaling Exacerbates a Mitochondrial Myopathy.

Sukru Anil Dogan, Raffaele Cerutti, Cristiane Benincá, Gloria Brea-Calvo, Howard Trevor Jacobs, Massimo Zeviani, Marten Szibor, Carlo Viscomi

Open access · hybridAbstract read
In one paragraph

Article in Cell metabolism, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers.

0numbers the graph read from it
0cells of the map it votes in
49citing papers in PubMed
4.6field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

49 citing papers in PubMed, 93 citations in OpenAlex.

  1. Article
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  8. Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  9. Alternative oxidase blunts pseudohypoxia and photoreceptor degeneration due to RPE mitochondrial dysfunction.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  10. Review
  11. Article
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  13. Article
  14. Knockout of the Complex III subunit Uqcrh causes bioenergetic impairment and cardiac contractile dysfunction.Mammalian genome : official journal of the International Mammalian Genome Society · 2023
    Article
  15. Why Don't More Mitochondrial Diseases Exhibit Cardiomyopathy?Journal of cardiovascular development and disease · 2023
    Article
  16. Review
  17. Review
  18. Article
  19. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 6 institutions in 3 countries.

Sukru Anil DoganMRC Mitochondrial Biology Unit, University of Cambridge, Wellcome Trust/MRC Building Hills Road, Cambridge CB2 0XY, UK.
Raffaele CeruttiMRC Mitochondrial Biology Unit, University of Cambridge, Wellcome Trust/MRC Building Hills Road, Cambridge CB2 0XY, UK.
Cristiane BenincáMRC Mitochondrial Biology Unit, University of Cambridge, Wellcome Trust/MRC Building Hills Road, Cambridge CB2 0XY, UK.
Gloria Brea-CalvoCentro Andaluz de Biología del Desarrollo and CIBERER, Instituto de Salud Carlos III, Universidad Pablo de Olavide-CSIC-JA, Sevilla 41013, Spain.
Howard Trevor JacobsInstitute of Biotechnology, University of Helsinki, Viikinkaari 5, Helsinki 00790, Finland; Faculty of Medicine and Life Sciences, University of Tampere, Arvo Ylpön katu 34, Tampere 33520, Finland.
Massimo ZevianiMRC Mitochondrial Biology Unit, University of Cambridge, Wellcome Trust/MRC Building Hills Road, Cambridge CB2 0XY, UK.
Marten SziborInstitute of Biotechnology, University of Helsinki, Viikinkaari 5, Helsinki 00790, Finland; Faculty of Medicine and Life Sciences, University of Tampere, Arvo Ylpön katu 34, Tampere 33520, Finland. Electronic address: marten.szibor@uta.fi.
Carlo ViscomiMRC Mitochondrial Biology Unit, University of Cambridge, Wellcome Trust/MRC Building Hills Road, Cambridge CB2 0XY, UK. Electronic address: cfv23@mrc-mbu.cam.ac.uk.
MRC Mitochondrial Biology Unit · GBUniversity of Cambridge · GBTampere University · FIUniversidad Pablo de Olavide · ESUniversity of Helsinki · FIWellcome Trust · GB

Funding

Medical Research Council MC_UP_1002/1Medical Research Council MC_UU_00015/5Medical Research Council MC_UU_00015/8
6 · The paper itself

Abstract

Alternative oxidases (AOXs) bypass respiratory complexes III and IV by transferring electrons from coenzyme Q directly to O

Indexed as

Signal TransductionAlternative OxidaseAnimalsAutophagyFemaleMaleMiceMice, Inbred C57BLMice, KnockoutMitochondrial MyopathiesMitochondrial ProteinsMuscle, SkeletalOrganelle BiogenesisOxidation-ReductionOxidoreductasesPlant ProteinsAlternative OxidaseMitochondrial ProteinsOxidoreductasesPlant ProteinsReactive Oxygen Speciesalternative oxidaseantioxidantautophagymitochondrial biogenesismitochondrial diseaseredox signalingROSsatellite cellsstress responses

Identifiers

PMID30122554
PMCPMC6224544
OpenAlexW2886044379

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.