ArticleCurrent biology : CB2018
Synaptic Transfer between Rod and Cone Pathways Mediated by AII Amacrine Cells in the Mouse Retina.
Article in Current biology : CB, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
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Who cites it
40 citing papers in PubMed.
- Population-level geometric filtering generates motion-coherence selectivity in the retina.Science advances · 2026Article
- Eyewire II - A connectomic resource for resolving cell types and circuits of the mouse retina.bioRxiv : the preprint server for biology · 2026Article
- Spatially local inhibition and synaptic plasticity together enable dynamic, context-dependent integration of parallel sensory pathways.Cell reports · 2026Article
- A hierarchical electrical synaptic circuit mechanism for integrative parallel visual processing in the retina.Neuron · 2026Article
- Junctional conductance of retinal AII amacrine cell electrical synapses is decreased by NMDA receptors.The Journal of physiology · 2026Article
- Nox3 expression and function in retinal ganglion cells and Amacrine cells.Cellular and molecular life sciences : CMLS · 2025Article
- A mechanism for pathological oscillations in mouse retinal ganglion cells in a model of night blindness.The Journal of general physiology · 2025Article
- Spatially-local inhibition and synaptic plasticity together enable dynamic, context-dependent integration of parallel sensory pathways.bioRxiv : the preprint server for biology · 2025Article
- A unipolar-driven synaptic transistor for environment-adaptable vision system.Nature communications · 2025Article
- Molecular mechanism establishing the OFF pathway in vision.Nature communications · 2025Article
- Enhanced restoration of visual code after targeting ON bipolar cells compared with retinal ganglion cells with optogenetic therapy.Molecular therapy : the journal of the American Society of Gene Therapy · 2025Article
- Temporal Transformation of the Rod Single-Photon Response in the Retinal Circuitry.Investigative ophthalmology & visual science · 2025Article
- A pupillary contrast response in mice and humans: Neural mechanisms and visual functions.Neuron · 2024Article
- Non-canonical type 1 cannabinoid receptor signaling regulates night visual processing in the inner rat retina.iScience · 2024Article
- A metabotropic glutamate receptor agonist enhances visual signal fidelity in a mouse model of retinitis pigmentosa.bioRxiv : the preprint server for biology · 2024Article
- Distributed feature representations of natural stimuli across parallel retinal pathways.Nature communications · 2024Article
- Article
- Layers of inhibitory networks shape receptive field properties of AII amacrine cells.Cell reports · 2023Article
- Functional maturation of the rod bipolar to AII-amacrine cell ribbon synapse in the mouse retina.Cell reports · 2023Article
- Cell numbers, cell ratios, and developmental plasticity in the rod pathway of the mouse retina.Journal of anatomy · 2023Review
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6 authors.
Funding
Abstract
To understand computation in a neural circuit requires a complete synaptic connectivity map and a thorough grasp of the information-processing tasks performed by the circuit. Here, we dissect a microcircuit in the mouse retina in which scotopic visual information (i.e., single photon events, luminance, contrast) is encoded by rod bipolar cells (RBCs) and distributed to parallel ON and OFF cone bipolar cell (CBC) circuits via the AII amacrine cell, an inhibitory interneuron. Serial block-face electron microscopy (SBEM) reconstructions indicate that AIIs preferentially connect to one OFF CBC subtype (CBC2); paired whole-cell patch-clamp recordings demonstrate that, depending on the level of network activation, AIIs transmit distinct components of synaptic input from single RBCs to downstream ON and OFF CBCs. These findings highlight specific synaptic and circuit-level features that allow intermediate neurons (e.g., AIIs) within a microcircuit to filter and propagate information to downstream neurons.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.