ArticleStem cell reports2018
Cell-Surface Marker Signature for Enrichment of Ventricular Cardiomyocytes Derived from Human Embryonic Stem Cells.
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Article in Stem cell reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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30citing papers in PubMed
2.8field-weighted citation impact, top 8% of its field
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Who cites it
30 citing papers in PubMed, 57 citations in OpenAlex.
- Altered Cohesin Dynamics During Cellular Differentiation.bioRxiv : the preprint server for biology · 2026Article
- Deep immune-phenotyping of HLA-homozygous iPS-cardiomyocytes by spectral flow cytometry.Frontiers in immunology · 2026Article
- CD47-mediated purification of human ventricular cardiomyocytes derived from pluripotent stem cells.Animal cells and systems · 2026Article
- Single-cell multi-modal integrative analyses highlight functional dynamic gene regulatory networks directing human cardiac development.Cell genomics · 2024Article
- Proteomics applications in next generation induced pluripotent stem cell models.Expert review of proteomics · 2024Review
- CD151 expression marks atrial- and ventricular- differentiation from human induced pluripotent stem cells.Communications biology · 2024Article
- Cellular heterogeneity of pluripotent stem cell-derived cardiomyocyte grafts is mechanistically linked to treatable arrhythmias.Nature cardiovascular research · 2024Article
- Enriching Cardiomyocytes Derived from hiPSCs by Magnetic-Activated Cell Sorting (MACS).Methods in molecular biology (Clifton, N.J.) · 2024Article
- JAK2 as a surface marker for enrichment of human pluripotent stem cells-derived ventricular cardiomyocytes.Stem cell research & therapy · 2023Article
- Human-gained heart enhancers are associated with species-specific cardiac attributes.Nature cardiovascular research · 2022Article
- Cardiac Cell Therapy with Pluripotent Stem Cell-Derived Cardiomyocytes: What Has Been Done and What Remains to Do?Current cardiology reports · 2022Review
- Direct coculture of human pluripotent stem cell-derived cardiac progenitor cells with epicardial cells induces cardiomyocyte proliferation and reduces sarcomere organization.Journal of molecular and cellular cardiology · 2022Article
- Cell surface markers for immunophenotyping human pluripotent stem cell-derived cardiomyocytes.Pflugers Archiv : European journal of physiology · 2021Review
- Myosin light chain 2 marks differentiating ventricular cardiomyocytes derived from human embryonic stem cells.Pflugers Archiv : European journal of physiology · 2021Article
- Model Systems for Addressing Mechanism of Arrhythmogenesis in Cardiac Repair.Current cardiology reports · 2021Review
- Cardiac cell type-specific gene regulatory programs and disease risk association.Science advances · 2021Article
- Regulatory Light Chains in Cardiac Development and Disease.International journal of molecular sciences · 2021Review
- Multiplexing physical stimulation on single human induced pluripotent stem cell-derived cardiomyocytes for phenotype modulation.Biofabrication · 2021Article
- Purification of Pluripotent Stem Cell-Derived Cardiomyocytes Using CRISPR/Cas9-Mediated Integration of Fluorescent Reporters.Methods in molecular biology (Clifton, N.J.) · 2021Article
- The quest of cell surface markers for stem cell therapy.Cellular and molecular life sciences : CMLS · 2021Review
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Authors and funding
23 authors at 3 institutions in 2 countries.
Jennifer VeeversSchool of Medicine, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA.
Elie N FarahSchool of Medicine, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA.
Mirko CorselliBD Biosciences, 11077 North Torrey Pines Road, La Jolla, CA 92037, USA.
Alec D WittySchool of Medicine, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA.
Karina PalomaresSchool of Medicine, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA.
Jason G VidalBD Biosciences, 11077 North Torrey Pines Road, La Jolla, CA 92037, USA.
Nil EmreBD Biosciences, 11077 North Torrey Pines Road, La Jolla, CA 92037, USA.
Christian T CarsonBD Biosciences, 11077 North Torrey Pines Road, La Jolla, CA 92037, USA.
Kunfu OuyangSchool of Medicine, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA; Drug Discovery Center, Key Laboratory of Chemical Genomics, Peking University Shenzhen Graduate School, Shenzhen 518055, China.
Canzhao LiuSchool of Medicine, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA.
Patrick van VlietSkaggs School of Pharmacy, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA.
Maggie ZhuSkaggs School of Pharmacy, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA.
Jeffrey M HegartySchool of Medicine, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA.
Dekker C DeaconSchool of Medicine, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA.
Jonathan D GrinsteinSchool of Medicine, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA.
Ralf J DirschingerSkaggs School of Pharmacy, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA.
Kelly A FrazerDepartment of Pediatrics, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA; Institute of Genomic Medicine, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA.
Eric D AdlerSchool of Medicine, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA.
Kirk U KnowltonSchool of Medicine, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA.
Neil C ChiSchool of Medicine, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA; Institute of Genomic Medicine, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA.
Jody C MartinBD Biosciences, 11077 North Torrey Pines Road, La Jolla, CA 92037, USA.
Ju ChenSchool of Medicine, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA. Electronic address: juchen@ucsd.edu.
Sylvia M EvansSchool of Medicine, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA; Skaggs School of Pharmacy, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA. Electronic address: syevans@ucsd.edu.
University of California, San Diego · USTorrey Pines Institute For Molecular Studies · USBD Biosciences (United States) · US
Funding
Administrative Coordinating Center: Cardiovascular Development and Pediatric Cardiac Genomics ConsortiaU01HL131003 · NHLBI · CINCINNATI CHILDRENS HOSP MED CTR · PI CNOTA, JAMES, OLLBERDING, NICHOLAS J · 2016 to 2024
$54.8MMEDICAL SCIENTIST TRAINING PROGRAMT32GM007198 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI CHI, NEIL C, INSEL, PAUL A · 1985 to 2024
$29.3MREGULATORY GENOMIC STUDIES IN A COHORT OF IPS CELL DERIVED CARDIOMYOCYTESU01HL107442 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI EVANS, SYLVIA M, FRAZER, KELLY A · 2011 to 2016
$9.8MU of Calif, San Diego Neuroscience Microscopy ImagingP30NS047101 · NINDS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI GLEESON, JOSEPH G, ZHENG, BINHAI · 2003 to 2022
$9.0MTraining Program in Basic Clinical GeneticsT32GM008666 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI HAMILTON, BRUCE A · 1998 to 2021
$8.6MDevelopmental Regulatory Genomics of Human Cardiovascular LineagesUM1HL128773 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI CHI, NEIL C, EVANS, SYLVIA M · 2015 to 2019
$3.8MThe role of Nexilin in cardiomyocyte and cardiomyopathyR01HL137957 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI CHEN, JU · 2017 to 2020
$1.6MBAG3 in Cardiac function and diseaseR01HL130295 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI CHEN, JU · 2016 to 2019
$1.6MLuma in Cardiac Function and DiseaseR01HL123626 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI CHEN, JU, EVANS, SYLVIA M · 2014 to 2017
$1.5MRegulatory Mechanisms of Cardiomyocyte Lineage SpecificationR01HL139709 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI CHI, NEIL C · 2018 to 2021
$1.2MNHLBI NIH HHS R01 HL123626NHLBI NIH HHS R01 HL130295NHLBI NIH HHS R01 HL137957NHLBI NIH HHS R01 HL139709NHLBI NIH HHS U01 HL107442NHLBI NIH HHS U01 HL131003NHLBI NIH HHS UM1 HL128773NIGMS NIH HHS T32 GM007198NIGMS NIH HHS T32 GM008666NINDS NIH HHS P30 NS047101
Abstract
To facilitate understanding of human cardiomyocyte (CM) subtype specification, and the study of ventricular CM biology in particular, we developed a broadly applicable strategy for enrichment of ventricular cardiomyocytes (VCMs) derived from human embryonic stem cells (hESCs). A bacterial artificial chromosome transgenic H9 hESC line in which GFP expression was driven by the human ventricular-specific myosin light chain 2 (MYL2) promoter was generated, and screened to identify cell-surface markers specific for MYL2-GFP-expressing VCMs. A CD77
Indexed as
Antigens, CDCardiac MyosinsCell DifferentiationCell LineCells, CulturedHeart VentriclesHuman Embryonic Stem CellsHumansMyocytes, CardiacMyosin Light ChainsTrihexosylceramidesAntigens, CDantigens, CD200Cardiac Myosinsglobotriaosylceramidemyosin light chain 2Myosin Light ChainsTrihexosylceramidescardiac differentiationcell-surface marker signaturehuman embryonic stem cellsventricular cardiomyocytes
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.