Evidence map›Paper›PMID 30122288›Full record

SynthesisBiological psychiatry2019

Associations Between Non-neurological Autoimmune Disorders and Psychosis: A Meta-analysis.

Alexis E Cullen, Scarlett Holmes, Thomas A Pollak, Graham Blackman, Dan W Joyce, Matthew J Kempton, Robin M Murray, Philip McGuire, Valeria Mondelli

Open access · hybridAbstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Biological psychiatry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 76 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
76citing papers in PubMed, 6 pooled it
5.3field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

76 citing papers in PubMed, 6 syntheses or guidelines pooled it, 155 citations in OpenAlex.

  1. Pooled it
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  3. CornealFrontiers in medicine · 2022
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  20. Autoantibodies and Inflammation in Schizophrenia.Psychiatry and clinical neurosciences · 2025
    Review

16 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Alexis E CullenDepartment of Psychosis Studies, South London and Maudsley NHS Foundation Trust, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, United Kingdom; National Institute for Health Research Maudsley Mental Health Biomedical Research Centre, South London and Maudsley NHS Foundation Trust, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, United Kingdom. Electronic address: alexis.cullen@kcl.ac.uk.
Scarlett HolmesDepartment of Psychosis Studies, South London and Maudsley NHS Foundation Trust, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, United Kingdom; National Institute for Health Research Maudsley Mental Health Biomedical Research Centre, South London and Maudsley NHS Foundation Trust, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, United Kingdom.
Thomas A PollakDepartment of Psychosis Studies, South London and Maudsley NHS Foundation Trust, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, United Kingdom; National Institute for Health Research Maudsley Mental Health Biomedical Research Centre, South London and Maudsley NHS Foundation Trust, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, United Kingdom.
Graham BlackmanDepartment of Psychosis Studies, South London and Maudsley NHS Foundation Trust, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, United Kingdom; National Institute for Health Research Maudsley Mental Health Biomedical Research Centre, South London and Maudsley NHS Foundation Trust, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, United Kingdom.
Dan W JoyceDepartment of Psychosis Studies, South London and Maudsley NHS Foundation Trust, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, United Kingdom; National Institute for Health Research Maudsley Mental Health Biomedical Research Centre, South London and Maudsley NHS Foundation Trust, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, United Kingdom.
Matthew J KemptonDepartment of Psychosis Studies, South London and Maudsley NHS Foundation Trust, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, United Kingdom; National Institute for Health Research Maudsley Mental Health Biomedical Research Centre, South London and Maudsley NHS Foundation Trust, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, United Kingdom.
Robin M MurrayDepartment of Psychosis Studies, South London and Maudsley NHS Foundation Trust, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, United Kingdom; National Institute for Health Research Maudsley Mental Health Biomedical Research Centre, South London and Maudsley NHS Foundation Trust, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, United Kingdom.
Philip McGuireDepartment of Psychosis Studies, South London and Maudsley NHS Foundation Trust, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, United Kingdom; National Institute for Health Research Maudsley Mental Health Biomedical Research Centre, South London and Maudsley NHS Foundation Trust, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, United Kingdom.
Valeria MondelliDepartment of Psychological Medicine, South London and Maudsley NHS Foundation Trust, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, United Kingdom; National Institute for Health Research Maudsley Mental Health Biomedical Research Centre, South London and Maudsley NHS Foundation Trust, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, United Kingdom.
King's College London · GB

Funding

Medical Research Council MR/J008915/1Wellcome Trust 105758/Z/14/ZWellcome Trust 107395/Z/15/Z
6 · The paper itself

Abstract

backgroundA relationship between non-neurological autoimmune (NNAI) disorders and psychosis has been widely reported but not yet subjected to meta-analysis. We conducted the first meta-analysis examining the association between NNAI disorders and psychosis and investigated the effect of 1) temporality (as determined by study design), 2) psychiatric diagnosis, and 3) specific autoimmune disorders.

methodsMajor databases were searched for articles published until April 2018; 31 studies, comprising data for >25 million individuals, were eligible. Using random-effects models, we examined the overall association between all NNAI disorders and psychosis; rheumatoid arthritis was examined separately given the well-established negative association with psychosis. Stratified analyses investigated the effect of temporality, psychiatric diagnosis, and specific NNAI disorders.

resultsWe observed a positive overall association between NNAI disorders and psychosis (odds ratio [OR] = 1.26; 95% confidence interval [CI], 1.12-1.41) that was consistent across study designs and psychiatric diagnoses; however, considerable heterogeneity was detected (I

conclusionsWhile we observed a positive overall association between NNAI disorders and psychosis, this was not consistent across all NNAI disorders. Specific factors, including distinct inflammatory pathways, genetic influences, autoantibodies targeting brain proteins, and exposure to corticosteroid treatment, may therefore underlie this association.

Indexed as

AutoantibodiesAutoimmune DiseasesAutoimmunityBrainHumansPsychotic DisordersRisk FactorsAutoantibodiesAutoimmuneEpidemiologyInflammationMeta-analysisPsychosisSchizophrenia

Identifiers

PMID30122288
PMCPMC6269125
OpenAlexW2810929521

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.