ArticleGenome biology2018
A simple genetic basis of adaptation to a novel thermal environment results in complex metabolic rewiring in Drosophila.
Article in Genome biology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 61 papers.
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Who cites it
61 citing papers in PubMed.
- Article
- Haplotype structure: an overlooked key factor shaping the genomic selection response.Genetics · 2026Article
- Molecular evolution in light of regulatory-coding epistasis.EMBO reports · 2026Review
- Experimental evolution to thermal stress indicates climate resilience in a cosmopolitan arthropod.eLife · 2026Article
- Evolutionary Dynamics of Gene Expression During Thermal Adaptation in Drosophila subobscura.Genome biology and evolution · 2026Article
- Repeatability of gene expression evolution in experimental environmental adaptation.Nature communications · 2026Article
- Reduced Parallel Gene Expression Evolution With Increasing Genetic Divergence-A Hallmark of Polygenic Adaptation.Molecular ecology · 2025Article
- Repeatability of evolution and genomic predictions of temperature adaptation in seed beetles.Nature ecology & evolution · 2025Article
- The evolution of thermal performance curves in response to rising temperatures across the model genus yeast.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Temperature and precipitation explain variation in metabolic rate but not frequency of gas exchange in Fijian bees.The Journal of experimental biology · 2025Article
- Life-history adaptation under climate warming magnifies the agricultural footprint of a cosmopolitan insect pest.Nature communications · 2025Article
- Article
- Zinc finger proteins facilitate adaptation of a global insect pest to climate change.BMC biology · 2024Article
- Genomic Diversity Illuminates the Environmental Adaptation of Drosophila suzukii.Genome biology and evolution · 2024Article
- Experimental Evolution in a Warming World: The Omics Era.Molecular biology and evolution · 2024Review
- A Path Integral Approach for Allele Frequency Dynamics Under Polygenic Selection.bioRxiv : the preprint server for biology · 2024Article
- Evolution of Phenotypic Variance Provides Insights into the Genetic Basis of Adaptation.Genome biology and evolution · 2024Article
- Thermal acclimation uncovers a simple genetic basis of adaptation to high temperature in a cosmopolitan pest.iScience · 2024Article
- Temperature and nutrition do not interact to shape the evolution of metabolic rate.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2024Article
- Genomewide architecture of adaptation in experimentally evolvedJournal of genetics · 2024Article
1 more citing papers are in PubMed but not listed here.
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5 authors.
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Abstract
backgroundPopulation genetic theory predicts that rapid adaptation is largely driven by complex traits encoded by many loci of small effect. Because large-effect loci are quickly fixed in natural populations, they should not contribute much to rapid adaptation.
resultsTo investigate the genetic architecture of thermal adaptation - a highly complex trait - we performed experimental evolution on a natural Drosophila simulans population. Transcriptome and respiration measurements reveal extensive metabolic rewiring after only approximately 60 generations in a hot environment. Analysis of genome-wide polymorphisms identifies two interacting selection targets, Sestrin and SNF4Aγ, pointing to AMPK, a central metabolic switch, as a key factor for thermal adaptation.
conclusionsOur results demonstrate that large-effect loci segregating at intermediate allele frequencies can allow natural populations to rapidly respond to selection. Because SNF4Aγ also exhibits clinal variation in various Drosophila species, we suggest that this large-effect polymorphism is maintained by temporal and spatial temperature variation in natural environments.
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