Evidence map›Paper›PMID 30121963›Full record

ArticleCancer medicine2018

Survival effect of different lymph node staging methods on ovarian cancer: An analysis of 10 878 patients.

Jieyu Wang, Jun Li, Ruifang Chen, Xin Lu

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PubMed Full text at PMC Publisher
In one paragraph

Article in Cancer medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 1 synthesis or guideline pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Jieyu WangDepartment of Gynecology, Obstetrics and Gynecology Hospital of Fudan University, Shanghai, China.
Jun LiDepartment of Gynecology, Obstetrics and Gynecology Hospital of Fudan University, Shanghai, China.
Ruifang ChenDepartment of Gynecology, Obstetrics and Gynecology Hospital of Fudan University, Shanghai, China.
Xin LuDepartment of Gynecology, Obstetrics and Gynecology Hospital of Fudan University, Shanghai, China.ORCID 0000-0003-1639-9549

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundTo compare the survival impact of several lymph node staging methods and therapeutic role of lymphadenectomy in patients with epithelial ovarian cancer who had undergone lymphadenectomy.

methodsData were retrospectively collected from the Surveillance, Epidemiology, and End Results program between 1988 and 2013.

resultsAn increasing number of resected lymph nodes (RLNs) was associated with a significant improvement in survival of FIGO stage II and III disease. However, for FIGO stage IV patients, better survival was not significantly associated with a more extensive lymphadenectomy. A higher lymph node ratio (LNR) and log odds of positive lymph nodes (LODDS) were associated with poorer survival regardless of stage. Nevertheless, four-category classification of LODDS was more suitable for stage IV patients when three-category classification was compatible with stage I-III disease. Multivariate analysis demonstrated that LODDS and LNR were significant independent prognostic factors, but not RLN classification.

conclusionSixteen to thirty RLNs are recommended for stage I disease. For stages II and III patients, the more lymph node excision, the better the prognosis. However, lymphadenectomy was nonessential for stage IV patients. Considering staging methods, for stages II and III patients, three-category classification of LODDS was recommended to evaluate the prognosis. For stage I and IV, three-category classification of positive LNR was idoneous.

Indexed as

AdolescentAdultAgedAged, 80 and overFemaleHumansKaplan-Meier EstimateLymphatic MetastasisMiddle AgedNeoplasm StagingOvarian NeoplasmsPrognosisRetrospective StudiesSEER ProgramYoung Adultepithelial ovarian cancerlog odds of positive lymph nodeslymphadenectomylymph node ratioresected lymph nodes

Identifiers

PMID30121963
PMCPMC6144146

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.