Evidence map›Paper›PMID 30121934›Full record

ArticleJournal of natural medicines2019

Shikonofuran E plays an anti-inflammatory role by down-regulating MAPK and NF-κB signaling pathways in lipopolysaccharide-stimulated RAW264.7 macrophages.

Lang Cao, Yong Xue, Zixiong Yang, Yanhong Li, Hongmei Li, Xuanqin Chen, Rongtao Li, Dan Liu

Abstract read
PubMed Publisher
In one paragraph

Article in Journal of natural medicines, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.0field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Exploration of targeted anti-tumor therapy · 2022
    Review
  3. Review
  4. Anti-Inflammatory and Antioxidant Effects ofMediators of inflammation · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Lang CaoMedicinal Chemistry, Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming, 650500, Yunnan, People's Republic of China.
Yong XueMedicinal Chemistry, Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming, 650500, Yunnan, People's Republic of China.
Zixiong YangMedicinal Chemistry, Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming, 650500, Yunnan, People's Republic of China.
Yanhong LiMedicinal Chemistry, Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming, 650500, Yunnan, People's Republic of China.
Hongmei LiMedicinal Chemistry, Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming, 650500, Yunnan, People's Republic of China.
Xuanqin ChenMedicinal Chemistry, Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming, 650500, Yunnan, People's Republic of China.
Rongtao LiMedicinal Chemistry, Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming, 650500, Yunnan, People's Republic of China.
Dan LiuMedicinal Chemistry, Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming, 650500, Yunnan, People's Republic of China. liudankm512@163.com.ORCID http://orcid.org/0000-0001-5176-9651
Kunming University of Science and Technology · CN

Funding

College Students Innovation and Entrepreneurship Training Program in Yunnan Province 201610674082Fund of State Key Laboratory of Phytochemistry and Plant Resources in West China P2015-KF01National Natural Science Foundation of China 21572082
6 · The paper itself

Abstract

The anti-inflammatory effects of shikonofuran E from Onosma paniculatum on RAW 264.7 murine macrophage cells induced by lipopolysaccharide (LPS) were first time examined. A series of non-cytotoxic concentrations of shikonofuran E (< 10 μM) treatments were found to reduce the accumulation of pro-inflammatory cytokine, including tumor necrosis factor-α (TNFα), interleukin-6 (IL-6), interleukin-1β (IL-1β), and inhibit the expression of nitric oxide synthase (iNOS) and cyclooxidase-2 (COX-2) in the LPS-stimulated macrophages as compared to the LPS-only treated cells. Nitric oxide (NO) production was also significantly suppressed in a dose-dependent manner (P < 0.05) with an IC

Indexed as

AnimalsAnti-Inflammatory AgentsDown-RegulationHumansLipopolysaccharidesMacrophagesMAP Kinase Kinase 1MAP Kinase Signaling SystemMiceNF-kappa BPhenolsPlant ExtractsRAW 264.7 CellsSignal TransductionAnti-Inflammatory AgentsLipopolysaccharidesMAP Kinase Kinase 1NF-kappa BPhenolsPlant ExtractsAnti-inflammatoryInflammatory mediatorsInflammatory signaling pathwayOnosma paniculatumShikonofuran E

Identifiers

PMID30121934
OpenAlexW2886675187

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.