ArticleEuropean journal of nutrition2019
Vitamin D deficiency is an independent predictor of mortality in patients with chronic heart failure.
Article in European journal of nutrition, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 38 citations in OpenAlex.
- Pooled it
- Association of Serum Vitamin D Levels With the Severity of Chronic Heart Failure: A Retrospective Study.Cureus · 2026Article
- [Interpretation of the Expert Consensus Statement on the Role of Vitamin D in Metabolic Health].Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery · 2026Article
- Modulation of Cardiometabolic Risk by Vitamin D and K2: Simple Supplementation or Real Drug? Uncovering the Pharmacological Properties.International journal of molecular sciences · 2025Review
- Cardiac allograft vasculopathy mediates the relationship between vitamin D deficiency and cardiovascular mortality following heart transplantation.American heart journal · 2025Article
- Vitamin D Deficiency and Clinical Outcomes in Critically Ill Pediatric Patients: A Systematic Review and Meta-Analysis.Journal of the Endocrine Society · 2025Review
- Association between Geriatric Nutritional Risk Index and all-cause mortality in individuals with osteoporotic fractures: a retrospective cohort study.Aging clinical and experimental research · 2025Article
- Vitamin D as a predictor of clinical response among patients with cardiac resynchronization therapy (CRT).Journal of arrhythmia · 2024Article
- Recent Advances in Association Between Vitamin D Levels and Cardiovascular Disorders.Current hypertension reports · 2023Review
- Diet variety sup the relationship between appetite and micronutrient intake in patients with heart failure.European journal of cardiovascular nursing · 2023Article
- Vitamin D, Cellular Senescence and Chronic Kidney Diseases: What Is Missing in the Equation?Nutrients · 2023Review
- Is Hypovitaminosis D a Risk Factor for Heart Failure?Life (Basel, Switzerland) · 2023Review
- Review
- The Role of Vitamin DJournal of clinical medicine · 2022Article
- Associations Between Vitamin D Levels and Risk of Heart Failure: A Bidirectional Mendelian Randomization Study.Frontiers in nutrition · 2022Article
- Impact of Vitamin D Supplementation on Bone Mineral Density and All-Cause Mortality in Heart Transplant Patients.Biomedicines · 2021Article
- Review
- Vitamin D and Cardiovascular Disease, with Emphasis on Hypertension, Atherosclerosis, and Heart Failure.International journal of molecular sciences · 2020Review
- Correlation of Vitamin D with Inflammatory Cytokines, Atherosclerotic Parameters, and Lifestyle Factors in the Setting of Heart Failure: A 12-Month Follow-Up Study.International journal of molecular sciences · 2019Article
- Vitamin D Deficiency Is a Predictor of Mortality in Elderly with Chronic Heart Failure.Acta endocrinologica (Bucharest, Romania : 2005)Article
Corrections and comments
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Authors and funding
11 authors at 2 institutions in 1 country.
Funding
Abstract
purposeLow 25-hydroxyvitamin D (25[OH]D) concentrations have been associated with adverse outcomes in selected populations with established chronic heart failure (CHF). However, it remains unclear whether 25[OH]D deficiency is associated with mortality and hospitalisation in unselected patients receiving contemporary medical and device therapy for CHF.
methodsWe prospectively examined the prevalence and correlates of 25[OH]D deficiency in 1802 ambulatory patients with CHF due to left ventricular systolic dysfunction (left ventricular ejection fraction ≤ 45%) attending heart failure clinics in the north of England.
results73% of patients were deficient in 25[OH]D (< 50 nmol/L). 25[OH]D deficiency was associated with male sex, diabetes, lower serum sodium, higher heart rate, and greater diuretic requirement. During a mean follow-up period of 4 years, each 2.72-fold increment in 25[OH]D concentration (for example from 32 to 87 nmol/L) is associated with 14% lower all-cause mortality (95% confidence interval (CI) 1, 26%; p = 0.04), after accounting for potential confounding factors.
conclusionsLow 25-hydroxyvitamin D deficiency is associated with increased mortality in patients with chronic heart failure due to left ventricular systolic dysfunction. Whether vitamin D supplementation will improve outcomes is, as yet, unproven.
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Registered trials
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