Evidence map›Paper›PMID 30121789›Full record

Trial reportSupportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer2019

Endurance and resistance training in patients with acute leukemia undergoing induction chemotherapy-a randomized pilot study.

Anja Wehrle, Sarah Kneis, Hans-Hermann Dickhuth, Albert Gollhofer, Hartmut Bertz

Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06134297 (Adherence, Feasibility, Clinical Evolution Therapeutic Efficacy of Three Different Muscle Overload Models Used for Physical Rehabilitation of Patients Undergoing Bone Marrow Transplantation), which is not on this map. Cited by 24 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed, 6 pooled it
5.8field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06134297 naunknown statusnot on this mapstarted 2022, after this paper: background citation

Adherence, Feasibility, Clinical Evolution Therapeutic Efficacy of Three Different Muscle Overload Models Used for Physical Rehabilitation of Patients Undergoing Bone Marrow Transplantation: a Randomized Clinical Trial

TypeinterventionalSponsorFederal University of Health Science of Porto AlegreRan2022 to 2024Enrolled93ConditionsStem Cell TransplantationArmsCycle ergometer, Strength Training - elastic band and shin guards, Cycle ergometer, elastic band and shin guards
3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 6 syntheses or guidelines pooled it, 51 citations in OpenAlex.

  1. Safety, feasibility, and effectiveness of exercise interventions in patients with hematologic malignancy during chemotherapy: a systematic review and meta-analysis.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2025
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  3. Effects of resistance training on quality of life, fatigue, physical function, and muscular strength during chemotherapy treatment: a systematic review and meta-analysis.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2024
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  7. Therapeutic Exercise Protocol During Hospitalization in Pediatric Oncohematological Patients: Randomized Clinical Trial.Physiotherapy research international : the journal for researchers and clinicians in physical therapy · 2026
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  19. Molecular mechanisms of exercise contributing to tissue regeneration.Signal transduction and targeted therapy · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Anja WehrleInstitute for Exercise- and Occupational Medicine, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany. anja.wehrle@uniklinik-freiburg.de.ORCID http://orcid.org/0000-0003-2436-7782
Sarah KneisDepartment of Medicine I (Specialties: Hematology, Oncology, and Stem-Cell Transplantation), Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
Hans-Hermann DickhuthInstitute for Exercise- and Occupational Medicine, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
Albert GollhoferDepartment of Sport and Sport Science, University of Freiburg, Freiburg, Germany.
Hartmut BertzDepartment of Medicine I (Specialties: Hematology, Oncology, and Stem-Cell Transplantation), Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
University of Freiburg · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeAcute leukemia (AL) and its initial treatment can impair physical functioning and capacity significantly. Exercise as a countermeasure has been investigated in few studies confirming its feasibility and safety during intensive induction chemotherapy, but the relative effects of diverse exercise programs have not been analyzed. Therefore, we aimed to investigate independent effects of endurance and resistance training on physical capacity and quality of life (QOL).

methodsTwenty-nine adult AL patients were randomly allocated to an endurance (EG), resistance (RG), or control (CG) group. The intervention took place during induction chemotherapy with three exercise sessions per week for 30-45 min each. Endurance capacity at individual anaerobic threshold, maximum knee extension and flexion strength, standardized phase angle (SPA), and QOL were measured at baseline prior to induction chemotherapy and before discharge.

resultsEndurance capacity changed in neither the EG, RG, or CG (P = 0.104); descriptively, the EG (- 0.05 W/kg) and RG (- 0.04 W/kg) exhibited a smaller decrease than CG (- 0.22 W/kg). We noted a significant difference in knee extension strength (P = 0.002); RG improved their maximum strength (+ 0.14 Nm/kg), while the EG's (- 0.13 Nm/kg) and CG's (- 0.19 Nm/kg) was significantly reduced. QOL and SPA revealed no change after the intervention.

conclusionsWe conclude that resistance training is a key component when exercising during induction chemotherapy: it improved maximum strength, but also influenced endurance capacity even during intensive treatment. Considering the prognostic value of physical function, we strongly propose integrating exercise, especially resistance-based training, already during induction chemotherapy to preserve AL patients' physical capacity and functional status.

Indexed as

Endurance TrainingInduction ChemotherapyResistance TrainingAdultExerciseExercise TherapyFemaleHumansLeukemia, Myeloid, AcuteMaleMiddle AgedMuscle StrengthPhysical EndurancePilot ProjectsQuality of LifeYoung AdultExercise therapyHematologic neoplasmsHospitalizationMuscle strengthPhysical enduranceQuality of life

Identifiers

PMID30121789
OpenAlexW2885054382

What OpenQuestion holds

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Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.