ArticleBMJ open2018
Risk of metabolic disorders in childless men: a population-based cohort study.
Article in BMJ open, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 26 citations in OpenAlex.
- A Systematic Review and Meta-Analysis of Male Infertility and the Subsequent Risk of Cancer.Frontiers in oncology · 2021Pooled it
- Risk of non-reproductive cancer in men from couples conceiving through assisted reproduction: a Swedish nation-based register study.European journal of epidemiology · 2026Article
- Are infertile men at a higher risk of morbidity and early mortality?Human reproduction (Oxford, England) · 2026Review
- Male Infertility and Reduced Life Expectancy: Epidemiology, Mechanisms, and Clinical Implications.Journal of clinical medicine · 2025Review
- Male Fertility as a Proxy for Health.Journal of clinical medicine · 2024Review
- Prevalence of impaired renal function among childless men as compared to fathers: a population-based study.Scientific reports · 2024Article
- Consumption of Sugar-Sweetened or Artificially Sweetened Beverages and Semen Quality in Young Men: A Cross-Sectional Study.International journal of environmental research and public health · 2022Article
- Association between Parenthood and Health Behaviour in Later Life-Results from the Population-Based CARLA Study.International journal of environmental research and public health · 2021Article
- Article
- Impact of genetic risk score on the association between male childlessness and cardiovascular disease and mortality.Scientific reports · 2021Article
- The Association Between Male Infertility and Cardiometabolic Disturbances: A Population-Based Study.International journal of endocrinology and metabolism · 2021Article
- Metabolic Syndrome and Reproduction.International journal of molecular sciences · 2021Review
- Hypertension and Reproduction.Current hypertension reports · 2020Review
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo study whether male childlessness is associated with an increased risk of metabolic disorders such as metabolic syndrome (MetS) and diabetes.
designA population-based cohort study.
settingNot applicable.
participants2572 men from the population-based Malmö Diet and Cancer Cardiovascular Cohort.
interventionsNone.
main outcome measuresFrom cross-sectional analyses, main outcome measures were ORs and 95% CIs for MetS and diabetes among childless men. In prospective analyses, HRs and 95% CI for diabetes among childless men.
resultsAt baseline, in men with a mean age of 57 years, the prevalence of MetS was 26% and 22% among childless men and fathers, respectively. Similarly, we observed a higher prevalence of diabetes of 11% among childless men compared with 5% among fathers. In the cross-sectional adjusted analyses, childless men had a higher risk of MetS and diabetes, with ORs of 1.22 (95% CI 0.87 to 1.72) and 2.12 (95% CI 1.34 to 3.36) compared with fathers. In the prospective analysis, during a mean follow-up of 18.3 years, we did not see any increase in diabetes risk among childless men (HR 1.02 (0.76 to 1.37)).
conclusionThis study provides evidence of an association between male childlessness and a higher risk of MetS and diabetes. However, as these associations were found in cross-sectional analyses, reverse causation cannot be excluded.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.