Evidence map›Paper›PMID 30121231›Full record

ReviewNeurobiology of disease2019

Modelling traumatic brain injury and posttraumatic epilepsy in rodents.

Rhys D Brady, Pablo M Casillas-Espinosa, Denes V Agoston, Edward H Bertram, Alaa Kamnaksh, Bridgette D Semple, Sandy R Shultz

Registry-linked trialOpen access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Neurobiology of disease, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04945213 (Biperiden for Prevention of Epilepsy in Patients With Traumatic Brain Injury), which is not on this map. Cited by 33 papers.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed
6.1field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04945213 phase3recruitingnot on this mapstarted 2023, after this paper: background citation

Biperiden for Prevention of Epilepsy in Patients With Traumatic Brain Injury

TypeinterventionalSponsorHospital Sirio-LibanesRan2023 to 2026Enrolled312ConditionsBrain Injury Traumatic Moderate, Brain Injury Traumatic Severe, Post Traumatic EpilepsyArmsBiperiden, Placebo
3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 67 citations in OpenAlex.

  1. Article
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  15. Levetiracetam Pharmacokinetics and Brain Uptake in a Lateral Fluid Percussion Injury Rat Model.The Journal of pharmacology and experimental therapeutics · 2023
    Article
  16. Observational
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Rhys D BradyDepartments of Neuroscience and Medicine, Central Clinical School, Monash University, VIC 3004, Australia; Department of Medicine, The Royal Melbourne Hospital, The University of Melbourne, VIC 3052, Australia. Electronic address: rhys.brady@monash.edu.
Pablo M Casillas-EspinosaDepartments of Neuroscience and Medicine, Central Clinical School, Monash University, VIC 3004, Australia; Department of Medicine, The Royal Melbourne Hospital, The University of Melbourne, VIC 3052, Australia. Electronic address: Pablo.Casillas-Espinosa@monash.edu.
Denes V AgostonAnatomy, Physiology & Genetics, Uniformed Services University, Bethesda, MD 20814, USA.
Edward H BertramDepartment of Neurology, University of Virginia, P.O. Box 800394, Charlottesville, VA 22908-0394, USA.
Alaa KamnakshAnatomy, Physiology & Genetics, Uniformed Services University, Bethesda, MD 20814, USA.
Bridgette D SempleDepartments of Neuroscience and Medicine, Central Clinical School, Monash University, VIC 3004, Australia; Department of Medicine, The Royal Melbourne Hospital, The University of Melbourne, VIC 3052, Australia.
Sandy R ShultzDepartments of Neuroscience and Medicine, Central Clinical School, Monash University, VIC 3004, Australia; Department of Medicine, The Royal Melbourne Hospital, The University of Melbourne, VIC 3052, Australia.
The Royal Melbourne Hospital · AUUniformed Services University of the Health Sciences · USUniversity of Virginia · US

Funding

The Epilepsy Bioinformatics Study for Antiepileptogenic Therapy (EpiBioS4Rx) Public Engagement CoreU54NS100064 · NINDS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI ENGEL, JEROME NONE, GALANOPOULOU, ARISTEA S · 2017 to 2021
$21.7M
NINDS NIH HHS U54 NS100064
6 · The paper itself

Abstract

Posttraumatic epilepsy (PTE) is one of the most debilitating and understudied consequences of traumatic brain injury (TBI). It is challenging to study the effects, underlying pathophysiology, biomarkers, and treatment of TBI and PTE purely in human patients for a number of reasons. Rodent models can complement human PTE studies as they allow for the rigorous investigation into the causal relationship between TBI and PTE, the pathophysiological mechanisms of PTE, the validation and implementation of PTE biomarkers, and the assessment of PTE treatments, in a tightly controlled, time- and cost-efficient manner in experimental subjects known to be experiencing epileptogenic processes. This article will review several common rodent models of TBI and/or PTE, including their use in previous studies and discuss their relative strengths, limitations, and avenues for future research to advance our understanding and treatment of PTE.

Indexed as

Disease Models, AnimalAnimalsBiomarkersBrain Injuries, TraumaticEpilepsy, Post-TraumaticHumansMiceRatsRisk FactorsTranslational Research, BiomedicalBiomarkersPosttraumatic epilepsyReviewTranslational researchTraumatic brain injury

Identifiers

PMID30121231
PMCPMC6348144
OpenAlexW2885917146

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.